Multiphoton Imaging for Deep Tissue Penetration

Tuesday, September 20, 2011

4:30pm | 203 Teer Building

Presenter

Chris Xu , Associate Professor, Department of Applied and Engineering Physics

Multiphoton microscopy (MPM) has been applied to imaging deep in scattering tissue  because of its intrinsic 3D localized excitation. However, the maximum imaging depth of high resolution MPM is still severely limited by strong tissue scattering. In this talk, the fundamental difficulties of deep tissue imaging will be discussed. Our research in longer wavelength MPM for deeper tissue penetration (up to ~1.6 mm in in vivo mouse brain) will be presented in detail. Advantages and limitations of the longer wavelength imaging will be discussed. Several practical issues, such as excitation sources, dye cross sections, tissue autofluorescence, etc., and potential future directions of long wavelength MPM for deep tissue imaging will be discussed.

Chris Xu received his B.S. in physics from Fudan University in 1989, and Ph.D. on multiphoton microscopy in Applied Physics, Cornell University in 1996. He joined Bell Laboratories (Murray Hill, NJ) in 1997 as a post-doc and then became a member of technical staff at Bell Labs (Holmdel, NJ) in 1999. His main research focus at Bell Labs was on fiber optics and optical communications. He returned to Cornell University in 2002, and became an Associate Professor and Director of Graduate Studies in Applied Physics in 2007. His current research areas are biomedical imaging, fiber optics, and optical communications. He has published more than 170 journal and conference papers, including 7 book chapters and 5 invited reviews, and has 25 patents granted or pending. He has won the NSF CAREER award, Bell Labs team research award, and the Tau Beta Pi and two other teaching awards from Cornell Engineering College. He is a fellow of the Optical Society of America.