Alberto Bartesaghi


Associate Professor of Computer Science

Appointments and Affiliations

  • Associate Professor of Computer Science
  • Faculty Network Member of the Duke Institute for Brain Sciences

Contact Information

  • Office Location: 308 Research Drive, LSRC D338, Durham, NC 27708-0129
  • Office Phone: (919) 660-6579
  • Email Address:
  • Websites:


  • D.Phil. University of Minnesota, Twin Cities, 2005

Research Interests

Image analysis, data science, computer vision, machine learning, image reconstruction, cryo-electron microscopy, protein structure

Courses Taught

  • BIOCHEM 393: Research Independent Study
  • BIOCHEM 562: High-Resolution Cryo-Electron Microscopy Image Analysis
  • BIOCHEM 593: Research Independent Study
  • BIOCHEM 690: Advanced Topics in Biochemistry
  • BIOCHEM 700: Graduate Training Internship
  • CBB 562: High-Resolution Cryo-Electron Microscopy Image Analysis
  • COMPSCI 290: Topics in Computer Science
  • COMPSCI 362: Introduction to Computational Imaging
  • COMPSCI 393: Research Independent Study
  • COMPSCI 562: High-Resolution Cryo-Electron Microscopy Image Analysis
  • COMPSCI 590: Advanced Topics in Computer Science

In the News

Representative Publications

  • Bouvette, J; Liu, H-F; Du, X; Zhou, Y; Sikkema, AP; da Fonseca Rezende E Mello, J; Klemm, BP; Huang, R; Schaaper, RM; Borgnia, MJ; Bartesaghi, A, Beam image-shift accelerated data acquisition for near-atomic resolution single-particle cryo-electron tomography., Nature Communications, vol 12 no. 1 (2021) [10.1038/s41467-021-22251-8] [abs].
  • Bartesaghi, A; Aguerrebere, C; Falconieri, V; Banerjee, S; Earl, LA; Zhu, X; Grigorieff, N; Milne, JLS; Sapiro, G; Wu, X; Subramaniam, S, Atomic Resolution Cryo-EM Structure of β-Galactosidase., Structure (London, England : 1993), vol 26 no. 6 (2018), pp. 848-856.e3 [10.1016/j.str.2018.04.004] [abs].
  • Kang, Y; Kuybeda, O; de Waal, PW; Mukherjee, S; Van Eps, N; Dutka, P; Zhou, XE; Bartesaghi, A; Erramilli, S; Morizumi, T; Gu, X; Yin, Y; Liu, P; Jiang, Y; Meng, X; Zhao, G; Melcher, K; Ernst, OP; Kossiakoff, AA; Subramaniam, S; Xu, HE, Cryo-EM structure of human rhodopsin bound to an inhibitory G protein., Nature, vol 558 no. 7711 (2018), pp. 553-558 [10.1038/s41586-018-0215-y] [abs].
  • Guo, TW; Bartesaghi, A; Yang, H; Falconieri, V; Rao, P; Merk, A; Eng, ET; Raczkowski, AM; Fox, T; Earl, LA; Patel, DJ; Subramaniam, S, Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex., Cell, vol 171 no. 2 (2017), pp. 414-426.e12 [10.1016/j.cell.2017.09.006] [abs].
  • Aguerrebere, C; Delbracio, M; Bartesaghi, A; Sapiro, G, Fundamental limits in multi-image alignment, Ieee Transactions on Signal Processing, vol 64 no. 21 (2016), pp. 5707-5722 [10.1109/TSP.2016.2600517] [abs].
  • Merk, A; Bartesaghi, A; Banerjee, S; Falconieri, V; Rao, P; Davis, MI; Pragani, R; Boxer, MB; Earl, LA; Milne, JLS; Subramaniam, S, Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery., Cell, vol 165 no. 7 (2016), pp. 1698-1707 [10.1016/j.cell.2016.05.040] [abs].