Amanda Elaine Hargrove

Hargrove

Associate Professor of Chemistry

The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs). The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “wild West.” Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids. Collaborations with the Department of Biology as well as colleagues in the School of Medicine ensure that these tools are applied to the most important unsolved problems in the fundamental biology and disease-related actions of long noncoding RNAs.

Appointments and Affiliations

  • Associate Professor of Chemistry
  • Assistant Professor in Biochemistry
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: 3219 French Science Center, Box 90346, Durham, NC 27708
  • Office Phone: (919) 660-1522
  • Email Address: amanda.hargrove@duke.edu
  • Websites:

Education

  • California Institute of Technology, 2013
  • Ph.D. University of Texas, Austin, 2010
  • B.S. Trinity University, 2004

Courses Taught

  • BIOCHEM 593: Research Independent Study
  • CHEM 201DL: Organic Chemistry I
  • CHEM 393: Research Independent Study
  • CHEM 394: Research Independent Study
  • CHEM 493: Research Independent Study
  • CHEM 494: Research Independent Study
  • CHEM 511: Chemistry of Biomolecular Interactions

In the News

Representative Publications

  • Donlic, A; Zafferani, M; Padroni, G; Puri, M; Hargrove, AE, Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans., Nucleic Acids Research, vol 48 no. 14 (2020), pp. 7653-7664 [10.1093/nar/gkaa585] [abs].
  • Padroni, G; Patwardhan, NN; Schapira, M; Hargrove, AE, Systematic analysis of the interactions driving small molecule-RNA recognition, Rsc Medicinal Chemistry, vol 11 no. 7 (2020), pp. 802-813 [10.1039/d0md00167h] [abs].
  • Umuhire Juru, A; Cai, Z; Jan, A; Hargrove, AE, Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry., Chemical Communications, vol 56 no. 24 (2020), pp. 3555-3558 [10.1039/d0cc00266f] [abs].
  • Ganser, LR; Kelly, ML; Patwardhan, NN; Hargrove, AE; Al-Hashimi, HM, Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States., J Mol Biol, vol 432 no. 4 (2020), pp. 1297-1304 [10.1016/j.jmb.2019.12.009] [abs].
  • Hargrove, AE, The next 20 years of Medicinal Research Reviews., Medicinal Research Reviews, vol 40 no. 1 (2020), pp. 7-8 [10.1002/med.21656] [abs].