Anna Mae Diehl


Florence McAlister Professor of Medicine, in the School of Medicine

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

Appointments and Affiliations

  • Florence McAlister Professor of Medicine, in the School of Medicine
  • Professor of Medicine
  • Professor in Molecular Genetics and Microbiology
  • Member of the Duke Cancer Institute
  • Affiliate of the Regeneration Next Initiative

Contact Information:

  • Office Location: Ste 1073, GSRB 1, 595 Lasalle Street, Durham, NC 27710
  • Office Phone: (919) 684-2366
  • Email Address:


  • Johns Hopkins University, 1984
  • Johns Hopkins University, 1981
  • M.D. Georgetown University, 1978

Awards, Honors, and Distinctions:

  • AASLD Distinguished Achievement Award. American Association for the Study of Liver Diseases. 2012
  • MERIT Award. National Institutes of Health. 2009

Courses Taught:

  • MGM 593: Research Independent Study

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