Bernard Martin Fischer

Fischer

Associate Professor of Pediatrics

Comparative Pharmacology and Cell Biology
Mechanisms of complementary-alternative medicines and products
Signal Transduction and Cell Signaling
Development of both animal and in vitro models of disease
Implications of early life lung injury on long-term immune function and overall health
Mechanisms of inflammation and disease
Cytokine, Oxidant, and Inflammatory Mediator Networking
Integrative care/treatments for HIV patients
Mechanisms of chronic inflammation associated with HIV

Appointments and Affiliations

  • Associate Professor of Pediatrics

Contact Information

  • Office Location: 139 MSRB1, 203 Research Drive, Durham, NC 27710
  • Office Phone: (919) 660-0258
  • Email Address: bernie.fischer@duke.edu

Education

  • Ph.D. North Carolina State University, 1997
  • D.V.M. North Carolina State University, 1988

Research Interests

Infant developing immune system in normal versus HIV infected or exposed infants
Chronic inflammation in adolescents with HIV and impact on neuro-cognitive function

Courses Taught

  • HOUSECS 59: House Course

Representative Publications

  • Meyer, ML; Potts-Kant, EN; Ghio, AJ; Fischer, BM; Foster, WM; Voynow, JA, NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia., American Journal of Physiology. Lung Cellular and Molecular Physiology, vol 303 no. 3 (2012), pp. L181-L188 [10.1152/ajplung.00084.2012] [abs].
  • Fischer, BM; Pavlisko, E; Voynow, JA, Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation., Int J Chron Obstruct Pulmon Dis, vol 6 (2011), pp. 413-421 [10.2147/COPD.S10770] [abs].
  • Foster, WM; Adler, KB; Crews, AL; Potts, EN; Fischer, BM; Voynow, JA, MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac., American Journal of Physiology. Lung Cellular and Molecular Physiology, vol 299 no. 3 (2010), pp. L345-L352 [10.1152/ajplung.00067.2010] [abs].
  • Fischer, BM; Domowicz, DAL; Zheng, S; Carter, JL; McElvaney, NG; Taggart, C; Lehmann, JR; Voynow, JA; Ghio, AJ, Neutrophil elastase increases airway epithelial nonheme iron levels., Clinical and Translational Science, vol 2 no. 5 (2009), pp. 333-339 [10.1111/j.1752-8062.2009.00151.x] [abs].
  • Voynow, JA; Fischer, BM; Zheng, S; Potts, EN; Grover, AR; Jaiswal, AK; Ghio, AJ; Foster, WM, NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans., American Journal of Respiratory Cell and Molecular Biology, vol 41 no. 1 (2009), pp. 107-113 [10.1165/rcmb.2008-0381OC] [abs].
  • Voynow, JA; Fischer, BM; Zheng, S, Proteases and cystic fibrosis., The International Journal of Biochemistry & Cell Biology, vol 40 no. 6-7 (2008), pp. 1238-1245 [10.1016/j.biocel.2008.03.003] [abs].
  • Fischer, BM; Zheng, S; Fan, R; Voynow, JA, Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1., American Journal of Physiology. Lung Cellular and Molecular Physiology, vol 293 no. 3 (2007), pp. L762-L768 [10.1152/ajplung.00067.2007] [abs].
  • Zheng, S; Byrd, AS; Fischer, BM; Grover, AR; Ghio, AJ; Voynow, JA, Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1., Free Radical Biology and Medicine, vol 42 no. 9 (2007), pp. 1398-1408 [10.1016/j.freeradbiomed.2007.01.040] [abs].
  • Voynow, JA; Fischer, BM; Roberts, BC; Proia, AD, Basal-like cells constitute the proliferating cell population in cystic fibrosis airways., American Journal of Respiratory and Critical Care Medicine, vol 172 no. 8 (2005), pp. 1013-1018 [10.1164/rccm.200410-1398oc] [abs].
  • Fischer, BM; Cuellar, JG; Byrd, AS; Rice, AB; Bonner, JC; Martin, LD; Voynow, JA, ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure., Faseb Journal, vol 19 no. 10 (2005), pp. 1374-1376 [10.1096/fj.04-2675fje] [abs].
  • Voynow, JA; Fischer, BM; Malarkey, DE; Burch, LH; Wong, T; Longphre, M; Ho, SB; Foster, WM, Neutrophil elastase induces mucus cell metaplasia in mouse lung., American Journal of Physiology. Lung Cellular and Molecular Physiology, vol 287 no. 6 (2004), pp. L1293-L1302 [10.1152/ajplung.00140.2004] [abs].
  • Krunkosky, TM; Martin, LD; Fischer, BM; Voynow, JA; Adler, KB, Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors., Free Radical Biology and Medicine, vol 35 no. 9 (2003), pp. 1158-1167 [10.1016/s0891-5849(03)00498-2] [abs].
  • Fischer, BM; Cuellar, JG; Diehl, ML; deFreytas, AM; Zhang, J; Carraway, KL; Voynow, JA, Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells., American Journal of Physiology. Lung Cellular and Molecular Physiology, vol 284 no. 4 (2003), pp. L671-L679 [10.1152/ajplung.00220.2002] [abs].
  • Fischer, BM; Voynow, JA, Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species., American Journal of Respiratory Cell and Molecular Biology, vol 26 no. 4 (2002), pp. 447-452 [10.1165/ajrcmb.26.4.4473] [abs].
  • Krunkosky, TM; Fischer, BM; Martin, LD; Jones, N; Akley, NJ; Adler, KB, Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro. Signaling pathways controlling surface and gene expression., American Journal of Respiratory Cell and Molecular Biology, vol 22 no. 6 (2000), pp. 685-692 [10.1165/ajrcmb.22.6.3925] [abs].
  • Voynow, JA; Young, LR; Wang, Y; Horger, T; Rose, MC; Fischer, BM, Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells., The American Journal of Physiology, vol 276 no. 5 (1999), pp. L835-L843 [10.1152/ajplung.1999.276.5.l835] [abs].
  • Fischer, BM; Rochelle, LG; Voynow, JA; Akley, NJ; Adler, KB, Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro., American Journal of Respiratory Cell and Molecular Biology, vol 20 no. 3 (1999), pp. 413-422 [10.1165/ajrcmb.20.3.3393] [abs].
  • Rochelle, LG; Fischer, BM; Adler, KB, Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro., Free Radical Biology and Medicine, vol 24 no. 5 (1998), pp. 863-868 [abs].
  • Martin, LD; Rochelle, LG; Fischer, BM; Krunkosky, TM; Adler, KB, Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators., The European Respiratory Journal, vol 10 no. 9 (1997), pp. 2139-2146 [abs].
  • Martin, LD; Krunkosky, TM; Dye, JA; Fischer, BM; Jiang, NF; Rochelle, LG; Akley, NJ; Dreher, KL; Adler, KB, The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates., Environmental Health Perspectives, vol 105 Suppl 5 (1997), pp. 1301-1307 [abs].
  • Wright, DT; Fischer, BM; Li, C; Rochelle, LG; Akley, NJ; Adler, KB, Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism., The American Journal of Physiology, vol 271 no. 5 Pt 1 (1996), pp. L854-L861 [10.1152/ajplung.1996.271.5.l854] [abs].
  • Krunkosky, TM; Fischer, BM; Akley, NJ; Adler, KB, Tumor necrosis factor alpha (TNF alpha)-induced ICAM-1 surface expression in airway epithelial cells in vitro: possible signal transduction mechanisms., Annals of the New York Academy of Sciences, vol 796 (1996), pp. 30-37 [abs].
  • Rochelle, LG; Fischer, BM; Krunkosky, TM; Wright, DT; Adler, KB, Environmental toxins induce intracellular responses of airway epithelium through reactive species of oxygen and nitrogen. Roger S. Mitchell Lecture., Chest, vol 109 no. 3 Suppl (1996), pp. 35S-39S [abs].
  • Adler, KB; Fischer, BM; Li, H; Choe, NH; Wright, DT, Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase., American Journal of Respiratory Cell and Molecular Biology, vol 13 no. 5 (1995), pp. 526-530 [10.1165/ajrcmb.13.5.7576687] [abs].
  • Fischer, BM; Krunkosky, TM; Wright, DT; Dolan-O'Keefe, M; Adler, KB, Tumor necrosis factor-alpha (TNF-alpha) stimulates mucin secretion and gene expression in airway epithelium in vitro., Chest, vol 107 no. 3 Suppl (1995), pp. 133S-135S [abs].
  • Adler, KB; Fischer, BM; Wright, DT; Cohn, LA; Becker, S, Interactions between respiratory epithelial cells and cytokines: relationships to lung inflammation., Annals of the New York Academy of Sciences, vol 725 (1994), pp. 128-145 [10.1111/j.1749-6632.1994.tb00275.x] [abs].
  • Price, GS; Page, RL; Fischer, BM; Levine, JF; Gerig, TM, Efficacy and toxicity of doxorubicin/cyclophosphamide maintenance therapy in dogs with multicentric lymphosarcoma., Journal of Veterinary Internal Medicine, vol 5 no. 5 (1991), pp. 259-262 [abs].