Bruce Klitzman


Associate Professor of Surgery

Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribution in the microcirculation,
2) the effects of long-term synthetic and biologic implants on substrate transport to tissues,
3) tissue engineering; combining isolated cells, especially adult stem cells, with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials.
4) decreasing the thrombogenicity of synthetic blood vessels and other blood-contacting devices, and improving their overall performance and biocompatibility.
5) reducing tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage.
6) biosensor function, particularly glucose sensors in normal and diabetics.
7) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential.
8) development of biocompatible materials for soft tissue reconstruction or augmentation.
9) improving performance of glaucoma drainage devices by directing a more favorable foreign body reaction
10) wound healing; particularly internal healing around foreign materials and the effect and prevention of microbes around implanted devices.

Appointments and Affiliations

  • Associate Professor of Surgery
  • Assistant Research Professor in Cell Biology
  • Associate Professor of Biomedical Engineering
  • Core Faculty in Innovation & Entrepreneurship

Contact Information:

  • Office Location: 479 & 487 Med Sci Res Bl 1, 203 Research Dr, 203 Research Dr, Durham, NC 27710
  • Office Phone: (919) 684-3929
  • Email Address:
  • Websites:


  • Ph.D. University of Virginia, 1979

Awards, Honors, and Distinctions:

  • Keynote Speaker. First International COnference on Tattoo Safety. 2013
  • Board Member. International Liaison Committee of Microcirculation Societies. 1999
  • Founder. North Carolina Tissue Engineering & Regenerative Medicine Society. 1998
  • President. The Microcirculatory Society. 1998

Courses Taught:

  • BME 493: Projects in Biomedical Engineering (GE)
  • CELLBIO 493: Research Independent Study

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