Eric John Toone


Professor Emeritus of Chemistry

Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry,
traditional enzymology, isothermal titration
microcalorimetry, and the techniques of directed evolution.

Appointments and Affiliations

  • Professor Emeritus of Chemistry
  • Faculty Network Member of The Energy Initiative
  • Bass Fellow

Contact Information

  • Office Location: 3236 French Science Center, Durham, NC 27708
  • Office Phone: +1 919 660 1506
  • Email Address:
  • Websites:


  • Ph.D. University of Toronto (Canada), 1988
  • M.S. University of Toronto (Canada), 1985
  • B.S. University of Guelph (Canada), 1983

Awards, Honors, and Distinctions

  • Sloan Research Fellowship-Chemistry. Alfred P. Sloan Foundation. 1995

Courses Taught

  • CHEM 493: Research Independent Study
  • CHEM 494: Research Independent Study

In the News

Representative Publications

  • Zhao, J; Cochrane, CS; Najeeb, J; Gooden, D; Sciandra, C; Fan, P; Lemaitre, N; Newns, K; Nicholas, RA; Guan, Z; Thaden, JT; Fowler, VG; Spasojevic, I; Sebbane, F; Toone, EJ; Duncan, C; Gammans, R; Zhou, P, Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens., Sci Transl Med, vol 15 no. 708 (2023) [10.1126/scitranslmed.adf5668] [abs].
  • Martorana, AM; Moura, ECCM; Sperandeo, P; Di Vincenzo, F; Liang, X; Toone, E; Zhou, P; Polissi, A, Degradation of Components of the Lpt Transenvelope Machinery Reveals LPS-Dependent Lpt Complex Stability in Escherichia coli., Front Mol Biosci, vol 8 (2021) [10.3389/fmolb.2021.758228] [abs].
  • Lemaître, N; Liang, X; Najeeb, J; Lee, C-J; Titecat, M; Leteurtre, E; Simonet, M; Toone, EJ; Zhou, P; Sebbane, F, Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC., mBio, vol 8 no. 4 (2017) [10.1128/mBio.00674-17] [abs].
  • Titecat, M; Liang, X; Lee, C-J; Charlet, A; Hocquet, D; Lambert, T; Pagès, J-M; Courcol, R; Sebbane, F; Toone, EJ; Zhou, P; Lemaitre, N, High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors., J Antimicrob Chemother, vol 71 no. 10 (2016), pp. 2874-2882 [10.1093/jac/dkw210] [abs].
  • Liang, X; Gopalaswamy, R; Navas, F; Toone, EJ; Zhou, P, A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058., J Org Chem, vol 81 no. 10 (2016), pp. 4393-4398 [10.1021/acs.joc.6b00589] [abs].