Jun Chen


Professor of Medicine

Appointments and Affiliations

  • Professor of Medicine
  • Affiliate of the Duke Regeneration Center
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: GSRB1 Rm 4004B, 905 S LaSalle Street, Durham, NC 27710
  • Office Phone: +1 919 681 3021
  • Email Address: chen0032@mc.duke.edu


  • Stanford University, School of Medicine, 1996
  • M.D. Sun Yat Sen University (China), 1991

Representative Publications

  • Chao, NJ; Chen, BJ, Prophylaxis and treatment of acute graft-versus-host disease., Semin Hematol, vol 43 no. 1 (2006), pp. 32-41 [10.1053/j.seminhematol.2005.09.007] [abs].
  • Hollingsworth, JW; Chen, BJ; Brass, DM; Berman, K; Gunn, MD; Cook, DN; Schwartz, DA, The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation., Am J Respir Crit Care Med, vol 171 no. 8 (2005), pp. 806-813 [10.1164/rccm.200407-953OC] [abs].
  • Le, NT; Chen, BJ; Chao, NJ, Selective elimination of alloreactivity from immunotherapeutic T cells by photodynamic cell purging and memory T-cell sorting., Cytotherapy, vol 7 no. 2 (2005), pp. 126-133 [10.1080/14653240510018163] [abs].
  • Chen, BJ; Cui, X; Sempowski, GD; Domen, J; Chao, NJ, Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation., Blood, vol 103 no. 11 (2004), pp. 4344-4352 [10.1182/blood-2003-07-2534] [abs].
  • Chen, BJ; Cui, X; Sempowski, GD; Liu, C; Chao, NJ, Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease., Blood, vol 103 no. 4 (2004), pp. 1534-1541 [10.1182/blood-2003-08-2987] [abs].
  • Chen, BJ; Cui, X; Sempowski, GD; Chao, NJ, Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice., Exp Hematol, vol 31 no. 10 (2003), pp. 953-958 [10.1016/s0301-472x(03)00196-6] [abs].
  • Chen, BJ; Cui, X; Liu, C; Chao, NJ, Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process., Blood, vol 99 no. 9 (2002), pp. 3083-3088 [10.1182/blood.v99.9.3083] [abs].
  • Chen, BJ; Cui, X; Chao, NJ, Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation., Blood, vol 99 no. 6 (2002), pp. 2235-2240 [10.1182/blood.v99.6.2235] [abs].
  • Chen, BJ; Chen, Y; Cui, X; Fidler, JM; Chao, NJ, Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model., Transplantation, vol 73 no. 1 (2002), pp. 115-121 [10.1097/00007890-200201150-00022] [abs].
  • Chao, NJ; Liu, CX; Rooney, B; Chen, BJ; Long, GD; Vredenburgh, JJ; Morris, A; Gasparetto, C; Rizzieri, DA, Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells., Biol Blood Marrow Transplant, vol 8 no. 5 (2002), pp. 249-256 [10.1053/bbmt.2002.v8.pm12064361] [abs].
  • Chen, BJ; Cui, X; Sempowski, GD; Gooding, ME; Liu, C; Haynes, BF; Chao, NJ, A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution., Blood, vol 99 no. 1 (2002), pp. 364-371 [10.1182/blood.v99.1.364] [abs].
  • Chen, BJ, Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F., Leuk Lymphoma, vol 42 no. 3 (2001), pp. 253-265 [10.3109/10428190109064582] [abs].
  • Klein, AK; Patel, DD; Gooding, ME; Sempowski, GD; Chen, BJ; Liu, C; Kurtzberg, J; Haynes, BF; Chao, NJ, T-Cell recovery in adults and children following umbilical cord blood transplantation., Biol Blood Marrow Transplant, vol 7 no. 8 (2001), pp. 454-466 [10.1016/s1083-8791(01)80013-6] [abs].
  • Chen, BJ; Liu, C; Cui, X; Fidler, JM; Chao, NJ, Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion., Transplantation, vol 70 no. 10 (2000), pp. 1442-1447 [10.1097/00007890-200011270-00008] [abs].
  • Chen, BJ; Morris, RE; Chao, NJ, Graft-versus-host disease prevention by rapamycin: cellular mechanisms., Biol Blood Marrow Transplant, vol 6 no. 5A (2000), pp. 529-536 [10.1016/s1083-8791(00)70062-0] [abs].
  • Schlegel, PG; Aharoni, R; Chen, Y; Chen, J; Teitelbaum, D; Arnon, R; Sela, M; Chao, NJ, A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo., Proc Natl Acad Sci U S A, vol 93 no. 10 (1996), pp. 5061-5066 [10.1073/pnas.93.10.5061] [abs].