Lingchong You
James L. Meriam Distinguished Professor of Biomedical Engineering
The You lab uses a combination of mathematical modeling, machine learning, and quantitative experiments to elucidate principles underlying the dynamics of microbial communities in time and space and to control these dynamics for applications in computation, engineering, and medicine.
Appointments and Affiliations
- James L. Meriam Distinguished Professor of Biomedical Engineering
- Professor of Biomedical Engineering
- Professor in Molecular Genetics and Microbiology
Contact Information
- Office Location: 1381 Ciemas, 101 Science Drive, Durham, NC 27708
- Office Phone: +1 919 660 8408
- Email Address: lingchong.you@duke.edu
- Websites:
Education
- Ph.D. University of Wisconsin, Madison, 2002
- M.S. University of Science and Technology of China (China), 1997
- B.S.E. Chengdu University of Science and Technology (China), 1994
Research Interests
Quantitative biology, synthetic biology, machine learning, antibiotic resistance, microbiome
Awards, Honors, and Distinctions
- Fellow. American Institute for Medical and Biological Engineering. 2019
- Faculty Early Career Development (CAREER) Program. National Science Foundation. 2010
- Young Professor Award. DuPont. 2008
- Fellowships for Science and Engineering. David and Lucile Packard Foundation. 2006
Courses Taught
- PHARM 394: Research Independent Study
- MGM 593: Research Independent Study
- EGR 393: Research Projects in Engineering
- CBB 574: Modeling and Engineering Gene Circuits (GE, MC)
- BME 792: Continuation of Graduate Independent Study
- BME 791: Graduate Independent Study
- BME 713S: QBio Seminar Series
- BME 590: Special Topics in Biomedical Engineering
- BME 574: Modeling and Engineering Gene Circuits (GE, MC)
- BME 494: Projects in Biomedical Engineering (GE)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 394: Projects in Biomedical Engineering (GE)
- BIOLOGY 293-1: Research Independent Study
In the News
- Resistant Bacteria Carry Extra Genes, According to Study (Feb 26, 2024 | Pratt School of Engineering)
- Synthetic Compartments Stop Pathogens from Sharing Antibiotic Resistance Genes (Feb 9, 2023 | Pratt School of Engineering)
- A Bacterial Message: ‘Be Sure to Drink Your Ovaltine’ (Sep 28, 2022 | Pratt School of Engineering)
- A Bacterial Message: ‘Be Sure to Drink Your Ovaltine’ (Sep 28, 2022 | Pratt School of Engineering)
- University Awards 24 New Distinguished Professorships (May 18, 2022)
- Tiny Jumping Genes Fingered as Culprit in Rise of Antibiotic Resistance (Apr 6, 2022 | Pratt School of Engineering)
- The Surprising Structural Reason Your Kitchen Sponge is Disgusting (Feb 17, 2022 | Pratt School of Engineering)
- Study Shows Some Bacteria Are Better Able to Share Resistance With Peers Than We Thought (Jan 29, 2020 | Pratt School of Engineering)
- Machine Learning Is Providing New Insights When the Biology Is Too Complex for Traditional Research (Oct 3, 2019 | Pratt School of Engineering)
- Distinguishing Resistance from Resilience to Prolong Antibiotic Potency (Dec 5, 2018 | Pratt School of Engineering)
- Where Are All the Germs? Students Explore Duke's Microbiome (Dec 7, 2017 | Center for Genomic and Computational Biology)
- Lingchong You: Tales of the genetically altered, superhero bacteria swarmbot (May 2, 2016 | WFDD-Winston-Salem’s “SciWorks Radio”)
- Biologists turn bacteria into 'swarmbots' (Mar 2, 2016 | Gizmodo)
- Engineered Swarmbots Rely on Peers for Survival (Feb 28, 2016 | Pratt School of Engineering)
- How Dividing Cells End Up the Same Size (Jun 3, 2015 | Pratt School of Engineering)
- Lingchong You comments: Paper test can detect Ebola strains (Oct 27, 2014 | BBC News)
- Chinese-Americans protest Kimmel skit in front of ABC station in downtown Raleigh (Nov 11, 2013 | The News & Observer)
- Growing Bacteria Keep Time, Know Their Place (Oct 8, 2013)
Representative Publications
- Luo, N; Lu, J; Şimşek, E; Silver, A; Yao, Y; Ouyang, X; West, SA; You, L, The collapse of cooperation during range expansion of Pseudomonas aeruginosa., Nature microbiology (2024) [10.1038/s41564-024-01627-8] [abs].
- Maddamsetti, R; Yao, Y; Wang, T; Gao, J; Huang, VT; Hamrick, GS; Son, H-I; You, L, Duplicated antibiotic resistance genes reveal ongoing selection and horizontal gene transfer in bacteria., Nature communications, vol 15 no. 1 (2024) [10.1038/s41467-024-45638-9] [abs].
- Baig, Y; Ma, HR; Xu, H; You, L, Autoencoder neural networks enable low dimensional structure analyses of microbial growth dynamics., Nature communications, vol 14 no. 1 (2023) [10.1038/s41467-023-43455-0] [abs].
- Weiss, A; Wang, T; You, L, Promotion of plasmid maintenance by heterogeneous partitioning of microbial communities., Cell systems, vol 14 no. 10 (2023), pp. 895-905.e5 [10.1016/j.cels.2023.09.002] [abs].
- Kim, K; Wang, T; Ma, HR; Şimşek, E; Li, B; Andreani, V; You, L, Mapping single-cell responses to population-level dynamics during antibiotic treatment, Molecular Systems Biology, vol 19 no. 7 (2023) [10.15252/msb.202211475] [abs].