Associate Research Professor in the Department of Chemistry
Dr. Fischer’s research focuses on exploring novel nonlinear optical contrast mechanisms for molecular imaging. Nonlinear optical microscopes can provide non-invasive, high-resolution, 3-dimensional images even in highly scattering environments such as biological tissue.
Established contrast mechanisms, such as two-photon fluorescence or harmonic generation, can image a range of targets (such as autofluorescent markers or some connective tissue structure), but many of the most molecularly specific nonlinear interactions are harder to measure with power levels one might be willing to put on tissue. In order to use these previously inaccessible interactions as structural and molecular image contrasts we are developing ultrafast laser pulse shaping and pulse shape detection methods that dramatically enhance measurement sensitivity. Applications of these microscopy methods range from imaging biological tissue (mapping structure, endogenous tissue markers, or exogenous contrast agents) to characterization of nanomaterials (such as graphene and gold nanoparticles). The molecular contrast mechanisms we originally developed for biomedical imaging also provide pigment-specific signatures for paints used in historic artwork. Recently we have demonstrated that we can noninvasively image paint layers in historic paintings and we are currently developing microscopy techniques for use in art conservation and conservation science.
Appointments and Affiliations
- Associate Research Professor in the Department of Chemistry
- Associate Research Professor of Physics
- Faculty Network Member of the Duke Institute for Brain Sciences
- Office Location: 2216 French Science Center, 124 Science Drive, Durham, NC 27708
- Office Phone: (919) 660-1523
- Ph.D. University of Texas at Austin, 2001
- M.A. University of Texas at Austin, 1993
In the News
- Shooting Lasers at Priceless Art (Jan 22, 2014)
- Ju, K-Y; Fischer, MC; Warren, WS, Understanding The Role Of Aggregation In The Broad Absorption Bands Of Eumelanin., Acs Nano (2018) [10.1021/acsnano.8b04905] [abs].
- Yu, J; Warren, WS; Fischer, MC, Spectroscopic Differentiation and Microscopic Imaging of Red Organic Pigments Using Optical Pump-Probe Contrast., Analytical Chemistry, vol 90 no. 21 (2018), pp. 12686-12691 [10.1021/acs.analchem.8b02949] [abs].
- Liu, X; Jia, X; Fischer, M; Huang, Z; Smith, DR, Enhanced Two-Photon Photochromism in Metasurface Perfect Absorbers., Nano Letters, vol 18 no. 10 (2018), pp. 6181-6187 [10.1021/acs.nanolett.8b02042] [abs].
- Stanton, IN; Ayres, JA; Stecher, JT; Fischer, MC; Scharpf, D; Scheuch, JD; Therien, MJ, Power-Dependent Radiant Flux and Absolute Quantum Yields of Upconversion Nanocrystals under Continuous and Pulsed Excitation, The Journal of Physical Chemistry C, vol 122 no. 1 (2018), pp. 252-259 [10.1021/acs.jpcc.7b11929] [abs].
- Wilson, JW; Robles, FE; Deb, S; Warren, WS; Fischer, MC, Comparison of pump-probe and hyperspectral imaging in unstained histology sections of pigmented lesions., Biomedical Optics Express, vol 8 no. 8 (2017), pp. 3882-3890 [10.1364/BOE.8.003882] [abs].