Richard T DiGiulio
Professor of Environmental Toxicology
Contact Information:
- Office Location: A346B LSRC
- Office Phone: (919) 613-8024
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Email Address:
Education:
| PhD | Virginia Polytechnic Institute and State University | |
| MS | Louisiana State University | |
| BA | University of Texas at Austin |
Dr. Di Giulio serves as Director of Duke University's Integrated Toxicology Program and the Superfund Basic Research Center. Dr. Di Giulio's research is concerned with basic studies of mechanisms of contaminant metabolism, adaptation and toxicity, and with the development of mechanistically-based indices of exposure and toxicity that can be employed in biomonitoring. The long term goals of this research are to bridge the gap between mechanistic toxicological research and the development of useful tools for environmental assessment, and to elucidate linkages between human and ecosystem health. The bulk of Dr. Di Giulio's work employs a comparative approach with aquatic animals, particularly fishes, as models. Of particular concern are mechanisms of oxidative metabolism of aromatic hydrocarbons, mechanisms of free radical production and antioxidant defense, and mechanisms of chemical carcinogenesis, developmental perturbations and adaptations to contaminated environments by fishes.
Recent Publications: (More Publications)
- TT Lindberg, ES Bernhardt, R Bier, AM Helton, RB Merola, A Vengosh, RT Di Giulio, Cumulative impacts of mountaintop mining on an Appalachian watershed., Proceedings of the National Academy of Sciences of the United States of America, vol 108 no. 52 (2011), pp. 20929-34 [doi] [abs]
- MR Wiesner, GV Lowry, E Casman, PM Bertsch, CW Matson, RT Di Giulio, J Liu, MF Hochella Jr, Meditations on the ubiquity and mutability of nano-sized materials in the environment., ACS nano, vol 5 no. 11 (2011), pp. 8466-70 [doi] [abs]
- D Jung, CW Matson, LB Collins, G Laban, HM Stapleton, JW Bickham, JA Swenberg, RT Di Giulio, Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia., Ecotoxicology (London, England), vol 20 no. 8 (2011), pp. 1890-9 [doi] [abs]
- BW Clark, RT Di Giulio, Fundulus heteroclitus adapted to PAHs are cross-resistant to multiple insecticides., Ecotoxicology (London, England) (2011) [doi] [abs]
- CR Fleming, RT Di Giulio, The role of CYP1A inhibition in the embryotoxic interactions between hypoxia and polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures in zebrafish (Danio rerio)., Ecotoxicology (London, England), vol 20 no. 6 (2011), pp. 1300-14 [doi] [abs]