Emily Rose Derbyshire
Assistant Professor of Chemistry
The Derbyshire Lab uses both chemical tools and biological methods to uncover novel aspects of malaria parasite biology with the ultimate aim of identifying druggable targets. Projects range from developing assays for phenotypic and target-based screens to exploring biological pathways and identifying small molecules with potential therapeutic value. Their interdisciplinary collaborative program integrates chemical biology, molecular biology and biochemistry to globally interrogate parasite biology.
Appointments and Affiliations
- Assistant Professor of Chemistry
- Assistant Professor in Molecular Genetics and Microbiology
- Office Location: 3218 French Science Center, Durham, NC 27708
- Office Phone: (919) 660-1511
- Email Address: firstname.lastname@example.org
- Harvard Medical School, 2014
- Ph.D. University of California - Berkeley, 2008
- B.S. Trinity College, 2002
- CHEM 89S: First-Year Seminar
- CHEM 393: Research Independent Study
- CHEM 394: Research Independent Study
- CHEM 493: Research Independent Study
- CHEM 494: Research Independent Study
- CHEM 517: Molecules in Life and Disease
- MGM 293: Research Independent Study I
- MGM 593: Research Independent Study
- PHARM 693: Research Independent Study in Science Education
In the News
- Thinking Big About Malaria, in the Lab and in the Classroom (Jun 4, 2020 | Trinity College of Arts and Sciences)
- Malaria Parasites Hijack Your Genes to Set up Camp Inside Your Liver (Jun 27, 2019)
- Malaria-Causing Parasite Manipulates Liver Cells to Survive (May 22, 2018)
- Two Duke Faculty Win NIH New Innovator Awards (Oct 5, 2017)
- Chemistry Professor Wins 2017 Marion Milligan Mason Award (Jan 11, 2017)
- Emily Derbyshire: Prospecting for Malaria Drugs (Oct 2, 2014)
- Cancer-Fighting Drugs Might Also Stop Malaria Early (Aug 25, 2014)
- Ganley, JG; Pandey, A; Sylvester, K; Lu, K-Y; Toro-Moreno, M; Rütschlin, S; Bradford, JM; Champion, CJ; Böttcher, T; Xu, J; Derbyshire, ER, A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity., Cell Chemical Biology, vol 27 no. 7 (2020), pp. 817-826.e5 [10.1016/j.chembiol.2020.06.004] [abs].
- Posfai, D; Maher, SP; Roesch, C; Vantaux, A; Sylvester, K; Péneau, J; Popovici, J; Kyle, DE; Witkowski, B; Derbyshire, ER, Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3., Cell Chemical Biology, vol 27 no. 6 (2020), pp. 719-727.e5 [10.1016/j.chembiol.2020.03.009] [abs].
- Ganley, JG; D'Ambrosio, HK; Shieh, M; Derbyshire, ER, Coculturing of Mosquito-Microbiome Bacteria Promotes Heme Degradation in Elizabethkingia anophelis., Chembiochem : a European Journal of Chemical Biology, vol 21 no. 9 (2020), pp. 1279-1284 [10.1002/cbic.201900675] [abs].
- Lu, K-Y; Quan, B; Sylvester, K; Srivastava, T; Fitzgerald, MC; Derbyshire, ER, Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy., Proceedings of the National Academy of Sciences of the United States of America, vol 117 no. 11 (2020), pp. 5810-5817 [10.1073/pnas.1913525117] [abs].
- Lu, K-Y; Derbyshire, ER, Tafenoquine: A Step toward Malaria Elimination., Biochemistry, vol 59 no. 8 (2020), pp. 911-920 [10.1021/acs.biochem.9b01105] [abs].