Biophotonics

The Biophotonics effort at the Fitzpatrick Institute for Photonics (FIP) is focused on developing a comprehensive, bottom-up approach toward non-invasive, early detection of disease where scientific and technological advances made at one level are incorporated into and drive the work at the next stage.

Optical coherence imaging techniques such as optical coherence tomography and phase-resolved microscopy provide powerful non-invasive modalities for real-time, micrometer-scale cross-sectional tissue imaging and ultrasensitive detection of cellular dynamics in vivo with microscopic scale resolution.

Diffuse optical tomography for measurements of hemodynamics and fluorescence and Raman techniques for spectroscopic diagnosis of disease, are important photonic modalities ready for translational research. We will extend our in vivo studies using fluorescence and Raman from the point-detection modality into a multispectral imaging modality.

An important goal of our clinically motivated research program is to create a multi-modality platform, whereby in vivo optical detection provides a complementary means to improve early detection and guidance for disease treatment. We will also investigate the use of novel molecular probes (nanoparticles, quantum dots, and plasmonics probes) as photonics contrast agents and molecular reporters of cellular events. We will investigate the development of molecular probes with multifunctional detection capabilities (OCT, diffuse scattering, fluorescence, and Raman).

By "multiplexing" these different photonics modalities, we will develop a novel type of hybrid biomedical system capable of detecting both chemical/molecular and morphological properties of tissue in vivo, which is not possible to conceive using only a single type of detection.

With a special focus on translational research, we will establish interdisciplinary collaborations with clinical investigators and draw upon various resources at Duke.

Biophotonics Faculty

David J. Brady

Michael J. Fitzpatrick Professor of Photonics in the Edmund T. Pratt, Jr. School of Engineering
David Brady leads the Duke Imaging and Spectroscopy Program (DISP), which builds computational imaging systems. DISP is currently focused on array...

Mark Wesley Dewhirst

Gustavo S. Montana Professor of Radiation Oncology, in the School of Medicine
Mark W. Dewhirst, DVM, PhD is the Gustavo S. Montana Professor of Radiation Oncology and Vice Director for Basic Science in the Duke Cancer Institute...

Katherine Schuver Garman

Assistant Professor of Medicine
My research focuses on injury, repair, and cancer development in the gastrointestinal tract. My laboratory performs translational research with the...

Yiyang Gong

Assistant Professor in the Department of Biomedical Engineering
We're interested in understanding brain function using the combination of genetically encoded sensors and optical techniques. Using genetically...

Russell P. Hall

J. Lamar Callaway Professor of Dermatology, in the School of Medicine
Our laboratory is investigating the pathogenesis of autoimmune blistering skin diseases. Areas of special expertise...

Joseph A. Izatt

Michael J. Fitzpatrick Professor of Engineering in the Edmund T. Pratt, Jr. School of Engineering
Biophotonics is concerned with the application of cutting-edge optoelectronic technologies to problems in the biomedical sciences. My research...

G. Allan Johnson

Charles E. Putman University Professor of Radiology
Dr. Johnson is the Charles E. Putman University Professor of Radiology, Professor of Physics, and Biomedical Engineering, and Director of the Duke...

Christopher Ryan Kelsey

Associate Professor of Radiation Oncology
Clinical trials that are currently enrolling patients include a study investigating lower doses of radiation therapy for patients with diffuse large...

David Guy Kirsch

Barbara Levine University Professor
My clinical interests are the multi-modality care of patients with bone and soft tissue sarcomas and developing new sarcoma therapies. My laboratory...

Anthony Nanlin Kuo

Assistant Professor of Ophthalmology

Barry S. Myers

Professor of Biomedical Engineering
Dr. Myers has been a member of the Duke faculty since 1991 and has just completed a three-year role as Managing Director of Licensing and Ventures....

James Michael Provenzale

Professor of Radiology
I have three major research areas: I. Applications of nanotechnology to treatment of cancer (both CNS and non-CNS) and brain disorders. I have a...

Nimmi Ramanujam

Robert W. Carr, Jr., Professor of Biomedical Engineering
Since coming to Duke University in 2005, Prof. Ramanujam has established the Tissue Optical Spectroscopy laboratory. Prof. Ramanujam's group is...

Allan B. Shang

Adjunct Assistant Professor of Biomedical Engineering
My current research interests include the investigation into current and experimental biosensors, including the use of lasers and photonic techniques...

Neil Lee Spector

Sandra Coates Associate Professor

Paul R. Stauffer

Professor of Radiation Oncology

Nathan Maclyn Thielman

Professor of Medicine
Broadly, my research focuses on a range of clinical and social issues that affect persons living with or at risk for HIV infection in resource-poor...

Cynthia Ann Toth

Joseph A.C. Wadsworth Professor of Ophthalmology
RESEARCH INTERESTS Dr. Toth specializes in the evaluation and surgical treatment of vitreoretinal diseases in adults and children and has pioneered...

George A. Truskey

R. Eugene and Susie E. Goodson Professor of Biomedical Engineering
My research interests focus upon the effect of physical forces on the function of vascular cells and skeletal muscle, cell adhesion, and the design...

Ganesan Vaidyanathan

Professor in Radiology
Dr. Vaidyanathan is a professor in the Department of Radiology.  He is a member of the Nuclear Medicine track of the Medical Physics Graduate...

Tuan Vo-Dinh

R. Eugene and Susie E. Goodson Professor of Biomedical Engineering
Dr. Tuan Vo-Dinh is R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering, Professor of Chemistry, and Director of The...

Warren S. Warren

James B. Duke Professor of Chemistry
Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter...

Adam P. Wax

Professor of Biomedical Engineering
Dr. Wax's research interests include optical spectroscopy for early cancer detection, novel microscopy and interferometry techniques. The study of...

Jennifer L West

Fitzpatrick Family University Professor of Engineering
Jennifer West’s research in biomaterials and tissue engineering involves the synthesis, development, and application of novel, biofunctional...

Heather Elizabeth Whitson

Associate Professor of Medicine
Dr. Whitson's research is focused on improving care and health outcomes for people with multiple chronic conditions.  In particular, she has...

Junjie Yao

Assistant Professor of Biomedical Engineering
Our mission at PI-Lab is to develop state-of-the-art photoacoustic tomography (PAT) technologies and translate PAT advances into diagnostic and...

Michael Rod Zalutsky

Jonathan Spicehandler, M.D. Professor of Neuro Oncology, in the School of Medicine
The overall objective of our laboratory is the development of novel radioactive compounds for improving the diagnosis and treatment of cancer. This...