Shyni Varghese

Varghese

Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery

Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.

A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:

  • Musculoskeletal tissue repair
  • Disease biophysics, and
  • Organ-on-a-chip technology

A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.

Appointments and Affiliations

  • Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
  • Professor of Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Duke Regeneration Center

Contact Information

Education

  • Ph.D. National Chemical Laboratory (India), 2002

Research Interests

Musculoskeletal tissue repair, disease biophysics and organ-on-a-chip technology

Courses Taught

  • NEUROSCI 494: Research Independent Study 2
  • NEUROSCI 493: Research Independent Study 1
  • ME 592: Research Independent Study in Mechanical Engineering or Material Science
  • ME 591: Research Independent Study in Mechanical Engineering or Material Science
  • EGR 393: Research Projects in Engineering
  • BME 792: Continuation of Graduate Independent Study
  • BME 791: Graduate Independent Study
  • BME 590: Special Topics in Biomedical Engineering
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 394: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Cottrill, E; Pennington, Z; Sattah, N; Jing, C; Salven, D; Johnson, E; Downey, M; Varghese, S; Rocos, B; Richardson, W, Gene Therapy and Spinal Fusion: Systematic Review and Meta-Analysis of the Available Data., World Neurosurg, vol 186 (2024), pp. 219-234.e4 [10.1016/j.wneu.2024.03.174] [abs].
  • Gonzales, G; Hoque, J; Gilpin, A; Maity, B; Zauscher, S; Varghese, S, Branched poly-l-lysine for cartilage penetrating carriers., Bioengineering & translational medicine, vol 9 no. 3 (2024) [10.1002/btm2.10612] [abs].
  • Hainline, KM; Haddad, HF; Gilpin, A; Curvino, EJ; Varghese, S; Collier, JH, Active immunotherapy for C5a-mediated inflammation using adjuvant-free self-assembled peptide nanofibers., Acta Biomater, vol 179 (2024), pp. 83-94 [10.1016/j.actbio.2024.02.042] [abs].
  • Price, MJ; Nguyen, AD; Haines, C; Baëta, CD; Byemerwa, J; Murkajee, D; Artham, S; Kumar, V; Lavau, C; Wardell, S; Varghese, S; Goodwin, CR, UDP-6-glucose dehydrogenase in hormonally responsive breast cancers., bioRxiv (2024) [10.1101/2024.03.20.585919] [abs].
  • Natesh, NR; Mogha, P; Chen, A; Antonia, SJ; Varghese, S, Differential roles of normal and lung cancer-associated fibroblasts in microvascular network formation., APL Bioeng, vol 8 no. 1 (2024) [10.1063/5.0188238] [abs].