Shyni Varghese


Professor of Orthopaedic Surgery

Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.

A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:

  • Musculoskeletal tissue repair
  • Disease biophysics, and
  • Organ-on-a-chip technology

A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.

Appointments and Affiliations

  • Professor of Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Duke Regeneration Center

Contact Information


  • Ph.D. National Chemical Laboratory (India), 2002

Research Interests

Musculoskeletal tissue repair, disease biophysics and organ-on-a-chip technology

Courses Taught

  • BME 290L: Intermediate Topics with Lab (GE)
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 590: Special Topics in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • ME 555: Advanced Topics in Mechanical Engineering
  • ME 591: Research Independent Study in Mechanical Engineering or Material Science
  • ME 592: Research Independent Study in Mechanical Engineering or Material Science

In the News

Representative Publications

  • Madhurakkat Perikamana, SK; Seale, N; Hoque, J; Ryu, JH; Kumar, V; Shih, YV; Varghese, S, Molecularly Tailored Interface for Long-Term Xenogeneic Cell Transplantation, Advanced Functional Materials, vol 32 no. 4 (2022) [10.1002/adfm.202108221] [abs].
  • Kumar, V; Madhurakkat Perikamana, SK; Tata, A; Hoque, J; Gilpin, A; Tata, PR; Varghese, S, An In Vitro Microfluidic Alveolus Model to Study Lung Biomechanics., Frontiers in Bioengineering and Biotechnology, vol 10 (2022) [10.3389/fbioe.2022.848699] [abs].
  • Gilpin, A; Zeng, Y; Hoque, J; Ryu, JH; Yang, Y; Zauscher, S; Eward, W; Varghese, S, Self-Healing of Hyaluronic Acid to Improve In Vivo Retention and Function., Adv Healthc Mater, vol 10 no. 23 (2021) [10.1002/adhm.202100777] [abs].
  • Andress, B; Kim, JH; Cutcliffe, HC; Amendola, A; Goode, AP; Varghese, S; DeFrate, LE; McNulty, AL, Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding., J Orthop Res, vol 39 no. 10 (2021), pp. 2177-2186 [10.1002/jor.24954] [abs].
  • Newman, H; Shih, YV; Varghese, S, Resolution of inflammation in bone regeneration: From understandings to therapeutic applications., Biomaterials, vol 277 (2021) [10.1016/j.biomaterials.2021.121114] [abs].