Alfred Winborne and Victoria Stover Mordecai Associate Professor of Biomedical Sciences
My research in biomedical simulation and high-performance computing focuses on the development of new computational tools that we use to provide insight into the localization and development of human diseases ranging from atherosclerosis to cancer.
Appointments and Affiliations
- Alfred Winborne and Victoria Stover Mordecai Associate Professor of Biomedical Sciences
- Associate Professor of Biomedical Engineering
- Assistant Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science
- Assistant Professor of Computer Science
- Member of the Duke Cancer Institute
Contact Information
- Office Location: Wilkinson Building, Room No. 325, 534 Research Drive, Durham, NC 27708
- Email Address: amanda.randles@duke.edu
- Websites:
Education
- Ph.D. Harvard University, 2013
Research Interests
Biomedical simulation and high-performance computing
Awards, Honors, and Distinctions
- Stansell Family Distinguished Research Award. Pratt School of Engineering. 2023
- Pioneer Award. NIH. 2022
- Fellow (NAI). National Academy of Inventors. 2021
- Senior Member. National Academy of Inventors. 2019
- IEEE-CS Technical Consortium on High Performance Computing (TCHPC) Award for Excellence for Early Career Researchers in High Performance Computing. IEEE. 2017
- Grace Murray Hopper Award. ACM. 2017
- MIT TR35 Visionary. MIT TR35. 2017
- Ralph E. Powe Junior Faculty Enhancement Award. Oak Ridge Associated Universities. 2016
- Best Paper, IEEE International Conference on Computational Science (ICCS) 2015. IEEE. 2015
- Gordon Bell Finalist. ACM. 2015
- Early Independence Award. NIH. 2014
- U.S. Delegate . Heidelberg Laureate Forum. 2013
- Lawrence Fellowship. Lawrence Livermore National Laboratory. 2013
- Anita Borg Memorial Scholarship. Google. 2012
- George Michael Memorial High Performance Computing Fellowship. ACM/IEEE. 2012
- U.S. Delegate . Lindau Nobel Laureates and Students Meeting Dedicated to Physics. 2012
- Gordon Bell Finalist. ACM. 2010
- Computational Science Graduate Fellowship. Department of Energy. 2010
- George Michael Memorial High Performance Computing Fellowship. ACM/IEEE. 2010
- Graduate Research Fellowship. National Science Foundation. 2009
Courses Taught
- EGR 393: Research Projects in Engineering
- BME 792: Continuation of Graduate Independent Study
- BME 791: Graduate Independent Study
- BME 590L: Special Topics with Lab
- BME 520L: Computational Foundations of Biomedical Simulation (GE, BB, MC)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 307: Transport Phenomena in Biological Systems (AC or GE, BB)
In the News
- New Method Using Smartwatch Data May Predict Heart Attack (Nov 29, 2023 | Pratt…
- Building a Community in Computational Medicine (Nov 17, 2023 | Pratt School of …
- Two Duke Faculty Have Won the NIH’s Prestigious Pioneer Award (Oct 3, 2022)
- Randles Elected Fellow of National Academy of Inventors (Dec 8, 2021 | Duke Eng…
- The Race to Split a Ventilator (Dec 9, 2020)
- Virtual Reality Blood Flow Simulation To Improve Cardiovascular Interventions (…
- Randles' Cancer Simulations Aims to Be Critical Step Toward Understanding Cance…
- A Revolutionary Picture of Blood Flow Opens New Avenues for Disease Diagnosis a…
- Randles Selected to Help Pilot First U.S. Exascale Computer (Jul 6, 2018 | Prat…
- Duke University Models How and Where Blood flow Impacts Health (Nov 1, 2017)
- Plumbing Virtual Vessels (Sep 21, 2017)
- Supercomputer copies whole-body blood flow (Mar 17, 2016 | BBC News)
- New Collaborative Seed Grant Program Gives Eight Awards (Mar 16, 2016)
- NIH Features Randles Research on Fighting Cancer With Supercomputers (Nov 19, 2…
- Experts put health issues firmly in the spotlight (Sep 14, 2015 | China Daily)
- Amanda Randles: Computing Complex Biological Systems (Jun 5, 2015 | Pratt Schoo…
Representative Publications
- Feiger, Bradley, Christopher W. Jensen, Benjamin S. Bryner, William P. Segars, and Amanda Randles. “Modeling the effect of patient size on cerebral perfusion during veno-arterial extracorporeal membrane oxygenation.” Perfusion 39, no. 7 (October 2024): 1295–1303. https://doi.org/10.1177/02676591231187962.
- Tanade, Cyrus, Nusrat Sadia Khan, Emily Rakestraw, William D. Ladd, Erik W. Draeger, and Amanda Randles. “Establishing the longitudinal hemodynamic mapping framework for wearable-driven coronary digital twins.” NPJ Digital Medicine 7, no. 1 (September 2024): 236. https://doi.org/10.1038/s41746-024-01216-3.
- Chidyagwai, Simbarashe G., Michael S. Kaplan, Christopher W. Jensen, James S. Chen, Reid C. Chamberlain, Kevin D. Hill, Piers C. A. Barker, Timothy C. Slesnick, and Amanda Randles. “Surgical Modulation of Pulmonary Artery Shear Stress: A Patient-Specific CFD Analysis of the Norwood Procedure.” Cardiovasc Eng Technol 15, no. 4 (August 2024): 431–42. https://doi.org/10.1007/s13239-024-00724-3.
- Geddes, Justen, Amanda Randles, Cyrus Tanade, William Ladd, and Nusrat Sadia Khan. “Velocity Temporal Shape Affects Simulated Flow in Left Coronary Arteries (Accepted),” 2024.
- Vardhan, Madhurima, Cyrus Tanade, S James Chen, Owais Mahmood, Jaidip Chakravartti, W Schuyler Jones, Andrew M. Kahn, et al. “Diagnostic Performance of Coronary Angiography Derived Computational Fractional Flow Reserve.” J Am Heart Assoc 13, no. 13 (July 2, 2024): e029941. https://doi.org/10.1161/JAHA.123.029941.