Professor Emeritus of Chemistry
Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.
Appointments and Affiliations
- Professor Emeritus of Chemistry
- Faculty Network Member of The Energy Initiative
- Bass Fellow
Contact Information
- Email Address: eric.toone@duke.edu
- Websites:
Education
- B.S. University of Guelph (Canada), 1983
- M.S. University of Toronto (Canada), 1985
- Ph.D. University of Toronto (Canada), 1988
Awards, Honors, and Distinctions
- Sloan Research Fellowship-Chemistry. Alfred P. Sloan Foundation. 1995
In the News
- Duke Holds DC Panel Discussion on Universities and Entrepreneurship (Oct 6, 201…
- Toone Named to US Advisory Council Studying Entrepreneurship and American Innov…
- The Role of Higher Ed in Entrepreneurship (Jul 26, 2016 | Tech Crunch)
- Entrepreneurship and the 21st Century University (Jul 22, 2016)
- Q&A: Eric Toone on entrepreneurship, failure, and resliliency (Jun 15, 2016 | D…
- Is a different kind of Silicon Valley possible? (Mar 25, 2016 | The Atlantic)
- Triangle universities look to alumni to invest in startups (Mar 2, 2016 | The N…
- Triangle Universities Partnering to Attract Innovation Funding (Mar 1, 2016)
- Duke Pioneers Pathway to Philanthropy for Entrepreneurs Through New Program (No…
- Duke Board Updated on Academic, Financial Issues at Fall Meeting (Oct 2, 2015)
- Entrepreneurial 'Bullpen' opens in downtown Durham (Sep 1, 2015)
- Duke University, alumni eye investments in startups (Mar 12, 2015 | The News & …
- ‘Duke Angel Network’ To Connect Alumni Investors With Duke-Affiliated Startups …
- Duke's grand entrepreneurship experiment (and its 16 test subjects) (Sep 25, 20…
- Why Duke Is Promoting Entrepreneurship (Sep 12, 2014)
- New Innovation and Entrepreneurship Certificate (Apr 11, 2014)
Representative Publications
- Zhao, Jinshi, C Skyler Cochrane, Javaria Najeeb, David Gooden, Carly Sciandra, Ping Fan, Nadine Lemaitre, et al. “Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens.” Sci Transl Med 15, no. 708 (August 9, 2023): eadf5668. https://doi.org/10.1126/scitranslmed.adf5668.
- Martorana, Alessandra M., Elisabete C. C. M. Moura, Paola Sperandeo, Flavia Di Vincenzo, Xiaofei Liang, Eric Toone, Pei Zhou, and Alessandra Polissi. “Degradation of Components of the Lpt Transenvelope Machinery Reveals LPS-Dependent Lpt Complex Stability in Escherichia coli.” Front Mol Biosci 8 (2021): 758228. https://doi.org/10.3389/fmolb.2021.758228.
- Lemaître, Nadine, Xiaofei Liang, Javaria Najeeb, Chul-Jin Lee, Marie Titecat, Emmanuelle Leteurtre, Michel Simonet, Eric J. Toone, Pei Zhou, and Florent Sebbane. “Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC.” MBio 8, no. 4 (July 25, 2017). https://doi.org/10.1128/mBio.00674-17.
- Titecat, Marie, Xiaofei Liang, Chul-Jin Lee, Audrey Charlet, Didier Hocquet, Thierry Lambert, Jean-Marie Pagès, et al. “High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.” J Antimicrob Chemother 71, no. 10 (October 2016): 2874–82. https://doi.org/10.1093/jac/dkw210.
- Liang, Xiaofei, Ramesh Gopalaswamy, Frank Navas, Eric J. Toone, and Pei Zhou. “A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058.” J Org Chem 81, no. 10 (May 20, 2016): 4393–98. https://doi.org/10.1021/acs.joc.6b00589.