Huanghe Yang

Associate Professor of Biochemistry

Appointments and Affiliations

  • Associate Professor of Biochemistry
  • Associate Professor in Neurobiology
  • Associate Professor in Medicine
  • Assistant Professor of Cell Biology
  • Faculty Network Member of the Duke Institute for Brain Sciences

Contact Information

  • Office Location: 213 Nanaline H Duke, Box 3711, DUMC, Durham, NC 27710
  • Email Address: huanghe.yang@duke.edu
  • Websites:

Education

  • Ph.D. Washington University in St. Louis, 2008

Awards, Honors, and Distinctions

  • NIH Director's New Innovator Award. NIH. 2017
  • Pathway to Independence Award (K99/R00). NINDS. 2014

Courses Taught

  • BIOCHEM 593: Research Independent Study
  • BIOCHEM 393: Research Independent Study

In the News

Representative Publications

  • Zheng, Wang, Augustus J. Lowry, Harper E. Smith, Jiale Xie, Shaun Rawson, Chen Wang, Jin Ou, et al. “Structural and functional basis of mechanosensitive TMEM63 channelopathies.” Neuron, June 2, 2025. https://doi.org/10.1016/j.neuron.2025.05.009.
  • Liang, Pengfei, Yui-Chun Serena Wan, Ke Zoe Shan, Ryan Chou, Yang Zhang, Martha Delahunty, Sanjay Khandelwal, et al. “Targeting PIEZO1-TMEM16F Coupling to Mitigate Sickle Cell Disease Complications.” BioRxiv, May 31, 2025. https://doi.org/10.1101/2025.05.27.656389.
  • Zhang, Yang, Ke Z. Shan, Pengfei Liang, Augustus J. Lowry, Liping Feng, and Huanghe Yang. “PIEZO1 Drives Trophoblast Fusion and Placental Development.” BioRxiv, March 26, 2025. https://doi.org/10.1101/2025.03.25.645313.
  • Kawai, Takafumi, Ping Dong, Konstantin Bakhurin, Henry H. Yin, and Huanghe Yang. “Calcium-activated ion channels drive atypical inhibition in medial habenula neurons.” Sci Adv 11, no. 12 (March 21, 2025): eadq2629. https://doi.org/10.1126/sciadv.adq2629.
  • Lowry, Augustus J., Pengfei Liang, Mo Song, Yuichun Wan, Zhen-Ming Pei, Huanghe Yang, and Yang Zhang. “TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids.,” November 4, 2024. https://doi.org/10.7554/eLife.96957.