Jun Chen

Professor of Medicine

Appointments and Affiliations

  • Professor of Medicine
  • Affiliate of the Duke Regeneration Center
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: GSRB1 Rm 4004B, 905 S LaSalle Street, Durham, NC 27710
  • Email Address: chen0032@mc.duke.edu

Education

  • M.D. Sun Yat Sen University (China), 1991
  • Stanford University, School of Medicine, 1996

Representative Publications

  • Chao, Nelson J., and Benny J. Chen. “Prophylaxis and treatment of acute graft-versus-host disease.” Semin Hematol 43, no. 1 (January 2006): 32–41. https://doi.org/10.1053/j.seminhematol.2005.09.007.
  • Hollingsworth, John W., Benny J. Chen, David M. Brass, Katie Berman, M Dee Gunn, Donald N. Cook, and David A. Schwartz. “The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation.” Am J Respir Crit Care Med 171, no. 8 (April 15, 2005): 806–13. https://doi.org/10.1164/rccm.200407-953OC.
  • Le, N. T., B. J. Chen, and N. J. Chao. “Selective elimination of alloreactivity from immunotherapeutic T cells by photodynamic cell purging and memory T-cell sorting.” Cytotherapy 7, no. 2 (2005): 126–33. https://doi.org/10.1080/14653240510018163.
  • Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Jos Domen, and Nelson J. Chao. “Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation.” Blood 103, no. 11 (June 1, 2004): 4344–52. https://doi.org/10.1182/blood-2003-07-2534.
  • Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Congxiao Liu, and Nelson J. Chao. “Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease.” Blood 103, no. 4 (February 15, 2004): 1534–41. https://doi.org/10.1182/blood-2003-08-2987.
  • Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, and Nelson J. Chao. “Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice.” Exp Hematol 31, no. 10 (October 2003): 953–58. https://doi.org/10.1016/s0301-472x(03)00196-6.
  • Chen, Benny J., Xiuyu Cui, Congxiao Liu, and Nelson J. Chao. “Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process.” Blood 99, no. 9 (May 1, 2002): 3083–88. https://doi.org/10.1182/blood.v99.9.3083.
  • Chen, Benny J., Xiuyu Cui, and Nelson J. Chao. “Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation.” Blood 99, no. 6 (March 15, 2002): 2235–40. https://doi.org/10.1182/blood.v99.6.2235.
  • Chen, Benny J., Yanfei Chen, Xiuyu Cui, John M. Fidler, and Nelson J. Chao. “Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model.” Transplantation 73, no. 1 (January 15, 2002): 115–21. https://doi.org/10.1097/00007890-200201150-00022.
  • Chao, Nelson J., Cong X. Liu, Barbara Rooney, Benny J. Chen, Gwynn D. Long, James J. Vredenburgh, Ashley Morris, Cristina Gasparetto, and David A. Rizzieri. “Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells.” Biol Blood Marrow Transplant 8, no. 5 (2002): 249–56. https://doi.org/10.1053/bbmt.2002.v8.pm12064361.
  • Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Maria E. Gooding, Congxiao Liu, Barton F. Haynes, and Nelson J. Chao. “A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution.” Blood 99, no. 1 (January 1, 2002): 364–71. https://doi.org/10.1182/blood.v99.1.364.
  • Chen, B. J. “Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F.” Leuk Lymphoma 42, no. 3 (July 2001): 253–65. https://doi.org/10.3109/10428190109064582.
  • Klein, A. K., D. D. Patel, M. E. Gooding, G. D. Sempowski, B. J. Chen, C. Liu, J. Kurtzberg, B. F. Haynes, and N. J. Chao. “T-Cell recovery in adults and children following umbilical cord blood transplantation.” Biol Blood Marrow Transplant 7, no. 8 (2001): 454–66. https://doi.org/10.1016/s1083-8791(01)80013-6.
  • Chen, B. J., C. Liu, X. Cui, J. M. Fidler, and N. J. Chao. “Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion.” Transplantation 70, no. 10 (November 27, 2000): 1442–47. https://doi.org/10.1097/00007890-200011270-00008.
  • Chen, B. J., R. E. Morris, and N. J. Chao. “Graft-versus-host disease prevention by rapamycin: cellular mechanisms.” Biol Blood Marrow Transplant 6, no. 5A (2000): 529–36. https://doi.org/10.1016/s1083-8791(00)70062-0.
  • Schlegel, P. G., R. Aharoni, Y. Chen, J. Chen, D. Teitelbaum, R. Arnon, M. Sela, and N. J. Chao. “A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo.” Proc Natl Acad Sci U S A 93, no. 10 (May 14, 1996): 5061–66. https://doi.org/10.1073/pnas.93.10.5061.