Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.
A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:
- Musculoskeletal tissue repair
- Disease biophysics, and
- Organ-on-a-chip technology
A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.
Appointments and Affiliations
- Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
- Professor of Orthopaedic Surgery
- Professor in the Department of Mechanical Engineering and Materials Science
- Professor in the Department of Biomedical Engineering
- Affiliate of the Duke Regeneration Center
Contact Information
- Email Address: shyni.varghese@duke.edu
- Websites:
Education
- Ph.D. National Chemical Laboratory (India), 2002
Research Interests
Musculoskeletal tissue repair, disease biophysics and organ-on-a-chip technology
Courses Taught
- NEUROSCI 494: Research Independent Study 2
- NEUROSCI 493: Research Independent Study 1
- ME 592: Research Independent Study in Mechanical Engineering or Material Science
- ME 591: Research Independent Study in Mechanical Engineering or Material Science
- EGR 393: Research Projects in Engineering
- BME 792: Continuation of Graduate Independent Study
- BME 791: Graduate Independent Study
- BME 590: Special Topics in Biomedical Engineering
- BME 494: Projects in Biomedical Engineering (GE)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 394: Projects in Biomedical Engineering (GE)
In the News
- Protecting Bones from Cancer Treatment (Dec 5, 2023 | School of Medicine)
- Organ-on-a-chip: Better Health Care Through Superior Drug Testing (Nov 24, 2021…
- Soft Robotic Dragonfly Signals Environmental Disruptions (Mar 25, 2021 | Pratt …
- A Crystal Ball for the Decade Ahead (Jan 9, 2020)
- Engineering a Better Bandage to Promote Faster Healing (Dec 13, 2019 | Pratt Sc…
- Big Ideas on a Small Chip Surface (Nov 1, 2019 | Pratt School of Engineering)
- Researchers ID Pharmaceutical Target That Reverses Osteoporosis in Mice (Aug 22…
- Shyni Varghese: Making Miniature Models of Muscles, Bones and Tumors (Nov 18, 2…
Representative Publications
- Gonzales, Gavin, Jiaul Hoque, Colin Kaeo, Stefan Zauscher, and Shyni Varghese. “Grafting of cationic molecules to hyaluronic acid improves adsorption and cartilage lubrication.” Biomater Sci, August 9, 2024. https://doi.org/10.1039/d4bm00532e.
- Cottrill, Ethan, Zach Pennington, Nathan Sattah, Crystal Jing, Dave Salven, Eli Johnson, Max Downey, Shyni Varghese, Brett Rocos, and William Richardson. “Gene Therapy and Spinal Fusion: Systematic Review and Meta-Analysis of the Available Data.” World Neurosurg 186 (June 2024): 219-234.e4. https://doi.org/10.1016/j.wneu.2024.03.174.
- Gonzales, Gavin, Jiaul Hoque, Anna Gilpin, Biswanath Maity, Stefan Zauscher, and Shyni Varghese. “Branched poly-l-lysine for cartilage penetrating carriers.” Bioeng Transl Med 9, no. 3 (May 2024): e10612. https://doi.org/10.1002/btm2.10612.
- Hainline, Kelly M., Helena Freire Haddad, Anna Gilpin, Elizabeth J. Curvino, Shyni Varghese, and Joel H. Collier. “Active immunotherapy for C5a-mediated inflammation using adjuvant-free self-assembled peptide nanofibers.” Acta Biomater 179 (April 15, 2024): 83–94. https://doi.org/10.1016/j.actbio.2024.02.042.
- Price, Meghan J., Annee D. Nguyen, Corinne Haines, César D. Baëta, Jovita Byemerwa, Debarati Murkajee, Sandeep Artham, et al. “UDP-6-glucose dehydrogenase in hormonally responsive breast cancers.” BioRxiv, March 21, 2024. https://doi.org/10.1101/2024.03.20.585919.