Adjunct Professor in the Department of Pathology
Dr. Shen’s research interests lie at precision medicine and systems biology. His lab integrates engineering, computational and biological techniques to study cancer, stem cells, microbiota and the nervous system in the gut. This multidisciplinary work has been instrumental in initiating several translational clinical trials in precision therapy. He is the director of the Woo Center for Big Data and Precision Health (DAP) and a core member of the Center for Genomics and Computational Biology (GCB).
Appointments and Affiliations
- Adjunct Professor in the Department of Pathology
Contact Information
- Email Address: xiling.shen@duke.edu
- Websites:
Education
- B.Sc. Stanford University, 2001
- M.Sc. Stanford University, 2001
- Ph.D. Stanford University, 2008
- Ph.D. Stanford University, 2008
Research Interests
Precision medicine for cancer, regeneration, microbiome, and gut-brain axis. Multi-omics approaches including organoid, epigenetics, CRISPR, single-cell, metabolomics, machine learning, droplet microfluidics, humanized immune model and intravital imaging.
In the News
- The Cancer Microbiome Reveals Which Bacteria Live in Tumors (Jan 13, 2021 | Pra…
- A Rare Window Into the Workings of the Colon in a Live Animal (Dec 11, 2019 | P…
- Cancer Cells Adapt to Gorge on Sugar in the Liver (Apr 27, 2018 | Pratt School …
- Cancer Drug Helps Treat Tuberculosis (Apr 27, 2018)
- A literal window into the second brain in our stomachs (Jun 23, 2016 | Newsweek)
- A literal window into the second brain in our stomachs (Jun 13, 2016 | Newsweek)
- Window in mouse shows its ‘gut feelings’ (Jun 8, 2016 | Gizmag)
- Window in mouse shows its ‘gut feelings’ (Jun 8, 2016 | Gizmag)
- Real-time View of Enteric Nervous System Provides a Window to the Gut's Brain (…
- How Gut Inflammation Sparks Colon Cancer (Feb 4, 2016)
- Xiling Shen: An Engineering Approach to Biomedical Challenges (Feb 24, 2015 | P…
Representative Publications
- Huang, Qiang, Malkiel A. Cohen, Fernando C. Alsina, Garth Devlin, Aliesha Garrett, Jennifer McKey, Patrick Havlik, et al. “Intravital imaging of mouse embryos.” Science 368, no. 6487 (April 10, 2020): 181–86. https://doi.org/10.1126/science.aba0210.
- Kaelberer, Melanie Maya, Kelly L. Buchanan, Marguerita E. Klein, Bradley B. Barth, Marcia M. Montoya, Xiling Shen, and Diego V. Bohórquez. “A gut-brain neural circuit for nutrient sensory transduction.” Science 361, no. 6408 (September 21, 2018). https://doi.org/10.1126/science.aat5236.
- Bu, Pengcheng, Kai-Yuan Chen, Kun Xiang, Christelle Johnson, Scott B. Crown, Nikolai Rakhilin, Yiwei Ai, et al. “Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.” Cell Metab 27, no. 6 (June 5, 2018): 1249-1262.e4. https://doi.org/10.1016/j.cmet.2018.04.003.
- Bu, Pengcheng, Lihua Wang, Kai-Yuan Chen, Tara Srinivasan, Preetish Kadur Lakshminarasimha Murthy, Kuei-Ling Tung, Anastasia Kristine Varanko, et al. “A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer.” Cell Stem Cell 18, no. 2 (February 4, 2016): 189–202. https://doi.org/10.1016/j.stem.2016.01.006.
- Bu, Pengcheng, Kai-Yuan Chen, Joyce Huan Chen, Lihua Wang, Jewell Walters, Yong Jun Shin, Julian P. Goerger, et al. “A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells.” Cell Stem Cell 12, no. 5 (May 2, 2013): 602–15. https://doi.org/10.1016/j.stem.2013.03.002.