Fan Yuan


Professor of Biomedical Engineering

Dr. Yuan has extensive experiences in analysis of therapeutic agent transport in mammalian cells, tissues, and organs, and development of effective strategies, design principles, and new technologies that can be used to facilitate the transport. The goal of his research is to improve delivery of therapeutic agents to their targets, which is crucial in treatment and prevention of diseases. He has published >100 scientific papers in peer-reviewed journals, and a textbook on transport analysis in biological systems that has been used to teach undergraduate and graduate courses in many universities.

Appointments and Affiliations

  • Professor of Biomedical Engineering
  • Professor in Ophthalmology
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: Rm 1385, Fciemas, Duke Univers, Durham, NC 27708-0281
  • Office Phone: (919) 660-5411
  • Email Address:
  • Websites:


  • Ph.D. City University of New York, 1990
  • M.S. Peking University (China), 1985
  • B.S. Peking University (China), 1983

Research Interests

Principles and mechanisms of delivery for drugs, genes, and vaccines; pharmacokinetics; electrotransfer or electroporation technology; and tumor pathophysiology.

Awards, Honors, and Distinctions

  • Fellow. American Institute for Medical and Biological Engineering. 2007
  • CAREER Award. National Science Foundation. 2000
  • SPORE in Breast Cancer Career Development Award. Duke University Medical Center. 1996
  • IPM Innovative Instrumentation Award. The Microcirculatory Society. 1994
  • IPM Innovative Instrumentation Award. The Microcirculatory Society. 1993

Courses Taught

  • BME 530: Introduction to Tissue Biomechanics (GE, BB)
  • BME 577: Drug Delivery (GE, BB, MC)
  • BME 789: Internship in Biomedical Engineering
  • BME 791: Graduate Independent Study

Representative Publications

  • Jin, Z; Yuan, F, A Double-Permeability Poroelasticity Model for Fluid Transport in a Biological Tissue, Transport in Porous Media, vol 147 no. 1 (2023), pp. 169-195 [10.1007/s11242-023-01904-w] [abs].
  • Wu, F; Shen, MH; Yang, J; Wang, H; Mikhaylov, R; Clayton, A; Qin, X; Sun, C; Xie, Z; Cai, M; Wei, J; Liang, D; Yuan, F; Wu, Z; Fu, Y; Yang, Z; Sun, X; Tian, L; Yang, X, An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation, Ieee Electron Device Letters, vol 42 no. 4 (2021), pp. 577-580 [10.1109/LED.2021.3062292] [abs].
  • Wang, L; Chang, C-C; Sylvers, J; Yuan, F, A statistical framework for determination of minimal plasmid copy number required for transgene expression in mammalian cells., Bioelectrochemistry (Amsterdam, Netherlands), vol 138 (2021) [10.1016/j.bioelechem.2020.107731] [abs].
  • Sun, C; Wu, F; Fu, Y; Wallis, DJ; Mikhaylov, R; Yuan, F; Liang, D; Xie, Z; Wang, H; Tao, R; Shen, MH; Yang, J; Xun, W; Wu, Z; Yang, Z; Cang, H; Yang, X, Thin film Gallium nitride (GaN) based acoustofluidic Tweezer: Modelling and microparticle manipulation., Ultrasonics, vol 108 (2020) [10.1016/j.ultras.2020.106202] [abs].
  • Huang, J; Sachdeva, M; Xu, E; Robinson, TJ; Luo, L; Ma, Y; Williams, NT; Lopez, O; Cervia, LD; Yuan, F; Qin, X; Zhang, D; Owzar, K; Gokgoz, N; Seto, A; Okada, T; Singer, S; Andrulis, IL; Wunder, JS; Lazar, AJ; Rubin, BP; Pipho, K; Mello, SS; Giudice, J; Kirsch, DG, The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways., Mol Cancer Res, vol 18 no. 10 (2020), pp. 1534-1544 [10.1158/1541-7786.MCR-19-1170] [abs].