Research Professor in the Department of Chemistry
Dr. Fischer’s research focuses on exploring novel nonlinear optical contrast mechanisms for molecular imaging. Nonlinear optical microscopes can provide non-invasive, high-resolution, 3-dimensional images even in highly scattering environments such as biological tissue.
Established contrast mechanisms, such as two-photon fluorescence or harmonic generation, can image a range of targets (such as autofluorescent markers or some connective tissue structure), but many of the most molecularly specific nonlinear interactions are harder to measure with power levels one might be willing to put on tissue. In order to use these previously inaccessible interactions as structural and molecular image contrasts we are developing ultrafast laser pulse shaping and pulse shape detection methods that dramatically enhance measurement sensitivity. Applications of these microscopy methods range from imaging biological tissue (mapping structure, endogenous tissue markers, or exogenous contrast agents) to characterization of nanomaterials (such as graphene and gold nanoparticles). The molecular contrast mechanisms we originally developed for biomedical imaging also provide pigment-specific signatures for paints used in historic artwork. Recently we have demonstrated that we can noninvasively image paint layers in historic paintings and we are currently developing microscopy techniques for use in art conservation and conservation science.
Appointments and Affiliations
- Research Professor in the Department of Chemistry
- Faculty Network Member of the Duke Institute for Brain Sciences
- Office Location: 2216 French Science Center, 124 Science Drive, Durham, NC 27708
- Office Phone: (919) 660-1523
- Email Address: email@example.com
- Ph.D. University of Texas, Austin, 2001
- M.A. University of Texas, Austin, 1993
- PHYSICS 493: Research Independent Study
In the News
- Faculty Discuss Their Research on Why Masks Work (Aug 13, 2020)
- Here's Visible Proof Masks Work (Aug 9, 2020 | Duke Health News)
- Making the Unseen Visible: Chan Zuckerberg Initiative Invests in Duke Imaging Technology (Mar 19, 2019)
- Shooting Lasers at Priceless Art (Jan 22, 2014)
- Fischer, EP; Fischer, MC; Grass, D; Henrion, I; Warren, WS; Westman, E, Low-cost measurement of face mask efficacy for filtering expelled droplets during speech., Science Advances, vol 6 no. 36 (2020) [10.1126/sciadv.abd3083] [abs].
- Yu, J; Li, Z; Kolodziej, C; Kuyuldar, S; Warren, WS; Burda, C; Fischer, MC, Visualizing the impact of chloride addition on the microscopic carrier dynamics of MAPbI3 thin films using femtosecond transient absorption microscopy, The Journal of Chemical Physics, vol 151 no. 23 (2019), pp. 234710-234710 [10.1063/1.5127875] [abs].
- Fischer, M; Wilson, J; Degan, S; Warren, W; Zhang, J; Mitropoulos, T; Gainey, C; Simpson, MJ, Data from: In vivo pump-probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions in a mouse model (2019) [10.7924/r4cc0zp95] [abs].