Shyni Varghese


Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery

Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.

A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:

  • Musculoskeletal tissue repair
  • Disease biophysics, and
  • Organ-on-a-chip technology

A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.

Appointments and Affiliations

  • Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
  • Professor of Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Duke Regeneration Center

Contact Information


  • Ph.D. National Chemical Laboratory (India), 2002

Research Interests

Musculoskeletal tissue repair, disease biophysics and organ-on-a-chip technology

Courses Taught

  • NEUROSCI 494: Research Independent Study 2
  • NEUROSCI 493: Research Independent Study 1
  • ME 592: Research Independent Study in Mechanical Engineering or Material Science
  • ME 591: Research Independent Study in Mechanical Engineering or Material Science
  • EGR 393: Research Projects in Engineering
  • BME 792: Continuation of Graduate Independent Study
  • BME 791: Graduate Independent Study
  • BME 590: Special Topics in Biomedical Engineering
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 394: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Natesh, NR; Mogha, P; Chen, A; Antonia, SJ; Varghese, S, Differential roles of normal and lung cancer-associated fibroblasts in microvascular network formation., APL Bioeng, vol 8 no. 1 (2024) [10.1063/5.0188238] [abs].
  • Subramaniam, S; Akay, M; Anastasio, MA; Bailey, V; Boas, D; Bonato, P; Chilkoti, A; Cochran, JR; Colvin, V; Desai, TA; Duncan, JS; Epstein, FH; Fraley, S; Giachelli, C; Grande-Allen, KJ; Green, J; Guo, XE; Hilton, IB; Humphrey, JD; Johnson, CR; Karniadakis, G; King, MR; Kirsch, RF; Kumar, S; Laurencin, CT; Li, S; Lieber, RL; Lovell, N; Mali, P; Margulies, SS; Meaney, DF; Ogle, B; Palsson, B; A Peppas, N; Perreault, EJ; Rabbitt, R; Setton, LA; Shea, LD; Shroff, SG; Shung, K; Tolias, AS; van der Meulen, MCH; Varghese, S; Vunjak-Novakovic, G; White, JA; Winslow, R; Zhang, J; Zhang, K; Zukoski, C; Miller, MI, Grand Challenges at the Interface of Engineering and Medicine., IEEE Open J Eng Med Biol, vol 5 (2024), pp. 1-13 [10.1109/OJEMB.2024.3351717] [abs].
  • Shih, Y-RV; Kingsley, D; Newman, H; Hoque, J; Gupta, A; Lascelles, BDX; Varghese, S, Multi-Functional Small Molecule Alleviates Fracture Pain and Promotes Bone Healing., Adv Sci (Weinh), vol 10 no. 36 (2023) [10.1002/advs.202303567] [abs].
  • Guo, W; Hoque, J; Garcia Garcia, CJ; Spiller, KV; Leinroth, AP; Puviindran, V; Potnis, CK; Gunn, KA; Newman, H; Ishikawa, K; Fujimoto, TN; Neill, DW; Delahoussaye, AM; Williams, NT; Kirsch, DG; Hilton, MJ; Varghese, S; Taniguchi, CM; Wu, C, Radiation-induced bone loss in mice is ameliorated by inhibition of HIF-2α in skeletal progenitor cells., Sci Transl Med, vol 15 no. 724 (2023) [10.1126/scitranslmed.abo5217] [abs].
  • Cigliola, V; Shoffner, A; Lee, N; Ou, J; Gonzalez, TJ; Hoque, J; Becker, CJ; Han, Y; Shen, G; Faw, TD; Abd-El-Barr, MM; Varghese, S; Asokan, A; Poss, KD, Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer., Nat Commun, vol 14 no. 1 (2023) [10.1038/s41467-023-40486-5] [abs].