Emily Rose Derbyshire

Derbyshire

Assistant Professor of Chemistry

The Derbyshire Lab uses both chemical tools and biological methods to uncover novel aspects of malaria parasite biology with the ultimate aim of identifying druggable targets. Projects range from developing assays for phenotypic and target-based screens to exploring biological pathways and identifying small molecules with potential therapeutic value. Their interdisciplinary collaborative program integrates chemical biology, molecular biology and biochemistry to globally interrogate parasite biology.

Appointments and Affiliations

  • Assistant Professor of Chemistry
  • Assistant Professor in Molecular Genetics and Microbiology

Contact Information

  • Office Location: 3218 French Science Center, Durham, NC 27708
  • Office Phone: (919) 660-1511
  • Email Address: emily.derbyshire@duke.edu
  • Websites:

Education

  • Harvard Medical School, 2014
  • Ph.D. University of California at Berkeley, 2008
  • B.S. Trinity College, 2002

Courses Taught

  • CHEM 89S: First-Year Seminar
  • CHEM 393: Research Independent Study
  • CHEM 394: Research Independent Study
  • CHEM 493: Research Independent Study
  • CHEM 494: Research Independent Study
  • CHEM 517: Molecules in Life and Disease
  • MGM 293: Research Independent Study I
  • MGM 593: Research Independent Study
  • PHARM 693: Research Independent Study in Science Education

In the News

Representative Publications

  • Szamosvári, D; Sylvester, K; Schmid, P; Lu, K-Y; Derbyshire, ER; Böttcher, T, Close the ring to break the cycle: tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity., Chemical Communications, vol 55 no. 49 (2019), pp. 7009-7012 [10.1039/c9cc01689a] [abs].
  • Lee, H; Sylvester, K; Derbyshire, ER; Hong, J, Synthesis and Analysis of Natural-Product-Like Macrocycles by Tandem Oxidation/Oxa-Conjugate Addition Reactions., Chemistry (Weinheim an Der Bergstrasse, Germany), vol 25 no. 26 (2019), pp. 6500-6504 [10.1002/chem.201900620] [abs].
  • Raphemot, R; Eubanks, AL; Toro-Moreno, M; Geiger, RA; Hughes, PF; Lu, K-Y; Haystead, TAJ; Derbyshire, ER, Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites., Cell Chem Biol, vol 26 no. 3 (2019), pp. 411-419.e7 [10.1016/j.chembiol.2018.11.003] [abs].
  • Eubanks, AL; Perkins, MM; Sylvester, K; Ganley, JG; Posfai, D; Sanschargrin, PC; Hong, J; Sliz, P; Derbyshire, ER, In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors., Chemmedchem, vol 13 no. 23 (2018), pp. 2479-2483 [10.1002/cmdc.201800625] [abs].
  • Ganley, JG; Carr, G; Ioerger, TR; Sacchettini, JC; Clardy, J; Derbyshire, ER, Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes., Chembiochem : a European Journal of Chemical Biology, vol 19 no. 15 (2018), pp. 1590-1594 [10.1002/cbic.201800124] [abs].