Amanda Randles

Alfred Winborne and Victoria Stover Mordecai Associate Professor of Biomedical Sciences

My research in biomedical simulation and high-performance computing focuses on the development of new computational tools that we use to provide insight into the localization and development of human diseases ranging from atherosclerosis to cancer. 

Appointments and Affiliations

• Alfred Winborne and Victoria Stover Mordecai Associate Professor of Biomedical Sciences
• Associate Professor of Biomedical Engineering
• Assistant Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science
• Assistant Professor of Computer Science
• Member of the Duke Cancer Institute

Contact Information

• Office Location: Wilkinson Building, Room No. 325, 534 Research Drive, Durham, NC 27708
• Office Phone: +1 919 660 6962
• Email Address: amanda.randles@duke.edu
• Websites:
  • Randles Lab Site
  • Google Scholar

Education

• Ph.D. Harvard University, 2013

Research Interests

Biomedical simulation and high-performance computing

Awards, Honors, and Distinctions

• Stansell Family Distinguished Research Award. Pratt School of Engineering. 2023
• Pioneer Award. NIH. 2022
• Fellow (NAI). National Academy of Inventors. 2021
• Senior Member. National Academy of Inventors. 2019
• IEEE-CS Technical Consortium on High Performance Computing (TCHPC) Award for Excellence for Early Career Researchers in High Performance Computing. IEEE. 2017
• Grace Murray Hopper Award. ACM. 2017
• MIT TR35 Visionary. MIT TR35. 2017
• Ralph E. Powe Junior Faculty Enhancement Award. Oak Ridge Associated Universities. 2016
• Best Paper, IEEE International Conference on Computational Science (ICCS) 2015. IEEE. 2015
• Gordon Bell Finalist. ACM. 2015
• Early Independence Award. NIH. 2014
• Lawrence Fellowship. Lawrence Livermore National Laboratory. 2013
• U.S. Delegate . Heidelberg Laureate Forum. 2013
• U.S. Delegate . Lindau Nobel Laureates and Students Meeting Dedicated to Physics. 2012
• George Michael Memorial High Performance Computing Fellowship. ACM/IEEE. 2012
• Anita Borg Memorial Scholarship. Google. 2012
• George Michael Memorial High Performance Computing Fellowship. ACM/IEEE. 2010
• Gordon Bell Finalist. ACM. 2010
• Computational Science Graduate Fellowship. Department of Energy. 2010
• Graduate Research Fellowship. National Science Foundation. 2009

Courses Taught

• EGR 393: Research Projects in Engineering
• BME 792: Continuation of Graduate Independent Study
• BME 791: Graduate Independent Study
• BME 590L: Special Topics with Lab
• BME 520L: Computational Foundations of Biomedical Simulation (GE, BB, MC)
• BME 493: Projects in Biomedical Engineering (GE)
• BME 307: Transport Phenomena in Biological Systems (AC or GE, BB)

In the News

• New Method Using Smartwatch Data May Predict Heart Attack (Nov 29, 2023 | Pratt School of Engineering)
• Building a Community in Computational Medicine (Nov 17, 2023 | Pratt School of Engineering)
• Two Duke Faculty Have Won the NIH’s Prestigious Pioneer Award (Oct 3, 2022)
• Randles Elected Fellow of National Academy of Inventors (Dec 7, 2021 | Duke Engineering News)
• The Race to Split a Ventilator (Dec 9, 2020)
• Virtual Reality Blood Flow Simulation To Improve Cardiovascular Interventions (May 14, 2020 | Pratt School of Engineering)
• Randles' Cancer Simulations Aims to Be Critical Step Toward Understanding Cancer Metastasis (Sep 11, 2019 | Duke Cancer Institute)
• A Revolutionary Picture of Blood Flow Opens New Avenues for Disease Diagnosis and Treatment (Aug 8, 2019 | Pratt School of Engineering)
• Randles Selected to Help Pilot First U.S. Exascale Computer (Jul 6, 2018 | Pratt School of Engineering)
• Duke University Models How and Where Blood flow Impacts Health (Oct 31, 2017)
• Plumbing Virtual Vessels (Sep 20, 2017)
• Supercomputer copies whole-body blood flow (Mar 17, 2016 | BBC News)
• New Collaborative Seed Grant Program Gives Eight Awards (Mar 16, 2016)
• NIH Features Randles Research on Fighting Cancer With Supercomputers (Nov 19, 2015 | Duke Today)
• Experts put health issues firmly in the spotlight (Sep 14, 2015 | China Daily)
• Amanda Randles: Computing Complex Biological Systems (Jun 4, 2015 | Pratt School of Engineering)

Representative Publications

• Vardhan, M; Tanade, C; Chen, SJ; Mahmood, O; Chakravartti, J; Jones, WS; Kahn, AM; Vemulapalli, S; Patel, M; Leopold, JA; Randles, A, Diagnostic Performance of Coronary Angiography Derived Computational Fractional Flow Reserve., J Am Heart Assoc, vol 13 no. 13 (2024) [10.1161/JAHA.123.029941] [abs].
• Chidyagwai, SG; Kaplan, MS; Jensen, CW; Chen, JS; Chamberlain, RC; Hill, KD; Barker, PCA; Slesnick, TC; Randles, A, Surgical Modulation of Pulmonary Artery Shear Stress: A Patient-Specific CFD Analysis of the Norwood Procedure., Cardiovasc Eng Technol (2024) [10.1007/s13239-024-00724-3] [abs].
• Geddes, JR; Randles, A, Optimizing Temporal Waveform Analysis: A Novel Pipeline for Efficient Characterization of Left Coronary Artery Velocity Profiles., ArXiv (2024) [abs].
• Nan, J; Roychowdhury, S; Randles, A, Investigating the Influence of Heterogeneity Within Cell Types on Microvessel Network Transport., Cellular and molecular bioengineering, vol 16 no. 5-6 (2023), pp. 497-507 [10.1007/s12195-023-00790-y] [abs].
• Yousef, A; Randles, A, Enabling In Situ Visualization of Large-Scale Cellular Simulations (2023) [abs].