Professor of Biomedical Engineering
My research in biomedical simulation and high-performance computing focuses on the development of new computational tools that we use to provide insight into the localization and development of human diseases ranging from atherosclerosis to cancer.
Appointments and Affiliations
- Professor of Biomedical Engineering
- Assistant Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science
- Associate Professor of Computer Science
- Member of the Duke Cancer Institute
Contact Information
- Office Location: Wilkinson Building, Room No. 325, 534 Research Drive, Durham, NC 27708
- Email Address: amanda.randles@duke.edu
- Websites:
Education
- Ph.D. Harvard University, 2013
Research Interests
Biomedical simulation and high-performance computing
Awards, Honors, and Distinctions
- Gilbreth Lectureship. NAE. 2025
- Presidential Early Career Award for Scientists and Engineers (PECASE). National Science Foundation (NSF). 2025
- Jack Dongarra Early Career Award. ISC. 2024
- Emerging Woman Leader in Technical Computing. ACM SIGHPC. 2023
- ACM Prize in Computing. ACM. 2023
- Stansell Family Distinguished Research Award. Pratt School of Engineering. 2023
- Distinguished Member. ACM. 2023
- Pioneer Award. NIH. 2022
- Fellow, National Academy of Inventors. National Academy of Inventors. 2021
- Senior Member. National Academy of Inventors. 2019
- IEEE-CS Technical Consortium on High Performance Computing (TCHPC) Award for Excellence for Early Career Researchers in High Performance Computing. IEEE. 2017
- MIT TR35 Visionary. MIT TR35. 2017
- Grace Murray Hopper Award. ACM. 2017
- Ralph E. Powe Junior Faculty Enhancement Award. Oak Ridge Associated Universities. 2016
- Best Paper, IEEE International Conference on Computational Science (ICCS) 2015. IEEE. 2015
- Gordon Bell Finalist. ACM. 2015
- Early Independence Award. NIH. 2014
- U.S. Delegate. Heidelberg Laureate Forum. 2013
- Lawrence Fellowship. Lawrence Livermore National Laboratory. 2013
- Anita Borg Memorial Scholarship. Google. 2012
- George Michael Memorial High Performance Computing Fellowship. ACM/IEEE. 2012
- U.S. Delegate. Lindau Nobel Laureates and Students Meeting Dedicated to Physics. 2012
- Gordon Bell Finalist. ACM. 2010
- Computational Science Graduate Fellowship. Department of Energy. 2010
- George Michael Memorial High Performance Computing Fellowship. ACM/IEEE. 2010
- Graduate Research Fellowship. National Science Foundation. 2009
Courses Taught
- BME 791: Graduate Independent Study
- BME 520L: Computational Foundations of Biomedical Simulation (GE, BB, MC)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 307: Transport Phenomena in Biological Systems (AC or GE, BB)
In the News
- Resilience and Optimism at Duke’s 2026 Research Summit (May 21, 2026)
- New Center Brings Technological Advances to the Future of Health Care (Apr 10, …
- Creating Digital Twins to Save Lives (Mar 12, 2025)
- Building Digital Twins for Individualized Health Care (Dec 19, 2024 | Pratt Blu…
- Gaming Has Stereotypes. Here’s Why It’s More Than Child’s Play (Oct 21, 2024)
- New Method Using Smartwatch Data May Predict Heart Attack (Nov 29, 2023)
- Building a Community in Computational Medicine (Nov 17, 2023)
- Two Duke Faculty Have Won the NIH’s Prestigious Pioneer Award (Oct 3, 2022 | Du…
- Randles Elected Fellow of National Academy of Inventors (Dec 8, 2021 | Pratt Sc…
- The Race to Split a Ventilator (Dec 9, 2020)
- Virtual Reality Blood Flow Simulation To Improve Cardiovascular Interventions (…
- Randles' Cancer Simulations Aims to Be Critical Step Toward Understanding Cance…
- Duke University Models How and Where Blood Flow Impacts Health (Nov 7, 2017 | R…
- Plumbing Virtual Vessels (Sep 21, 2017)
- Supercomputer copies whole-body blood flow (Mar 17, 2016 | BBC News)
- New Collaborative Seed Grant Program Gives Eight Awards (Mar 16, 2016)
- NIH Features Randles Research on Fighting Cancer With Supercomputers (Nov 19, 2…
- Experts put health issues firmly in the spotlight (Sep 14, 2015 | China Daily)
Representative Publications
- Tanade, Cyrus, Japneet Kaur Mavi, Guinevere Ferreira, Sam Schwaller, and Amanda Randles. “Optimizing Non-invasive Fractional Flow Reserve Estimation with Machine Learning-Enhanced 1D Hemodynamic Modeling.” Cardiovascular Engineering and Technology 17, no. 4 (August 2026): 425–38. https://doi.org/10.1007/s13239-026-00836-y.
- Randles, Amanda. “Physiological Assessment of Coronary Artery Disease.” The New England Journal of Medicine 395, no. 1 (July 2026): 80–83. https://doi.org/10.1056/nejme2602134.
- Yousef, A., A. Martin, and A. Randles. “GPU Halo Replay: Lossless Twin Simulations for Flexible In Situ Analysis of Stencil-Based Solvers.” In Pasc 2026 Platform for Advanced Scientific Computing Conference, 2026. https://doi.org/10.1145/3815572.3815746.
- Tanade, Cyrus, Christopher W. Jensen, Guinevere Ferreira, and Amanda Randles. “Real-Time Peripheral Revascularization Planning in Chronic Limb Threatening Ischemia Using HarVI: A Digital Twin Approach.” Cardiovascular Engineering and Technology 17, no. 3 (June 2026): 300–316. https://doi.org/10.1007/s13239-026-00825-1.
- Mac Grory, Brian, Amanda Randles, David M. Urick, Fides R. Schwartz, David Hasan, and Evan D. Calabrese. “Photon-Counting CT for Evaluation of Coiled Intracranial Aneurysms.” AJNR Am J Neuroradiol 47, no. 4 (April 2, 2026): 912–19. https://doi.org/10.3174/ajnr.A9015.