Lingchong You

You

James L. Meriam Distinguished Professor of Biomedical Engineering

The You lab uses a combination of mathematical modeling, machine learning, and quantitative experiments to elucidate principles underlying the dynamics of microbial communities in time and space and to control these dynamics for applications in computation, engineering, and medicine.

Appointments and Affiliations

  • James L. Meriam Distinguished Professor of Biomedical Engineering
  • Professor of Biomedical Engineering
  • Professor in Molecular Genetics and Microbiology

Contact Information

  • Office Location: 1381 Ciemas, 101 Science Drive, Durham, NC 27708
  • Office Phone: +1 919 660 8408
  • Email Address: lingchong.you@duke.edu
  • Websites:

Education

  • Ph.D. University of Wisconsin, Madison, 2002
  • M.S. University of Science and Technology of China (China), 1997
  • B.S.E. Chengdu University of Science and Technology (China), 1994

Research Interests

Quantitative biology, synthetic biology, machine learning, antibiotic resistance, microbiome

Awards, Honors, and Distinctions

  • Fellow. American Institute for Medical and Biological Engineering. 2019
  • Faculty Early Career Development (CAREER) Program. National Science Foundation. 2010
  • Young Professor Award. DuPont. 2008
  • Fellowships for Science and Engineering. David and Lucile Packard Foundation. 2006

Courses Taught

  • PHARM 394: Research Independent Study
  • MGM 593: Research Independent Study
  • EGR 393: Research Projects in Engineering
  • CBB 574: Modeling and Engineering Gene Circuits (GE, MC)
  • BME 792: Continuation of Graduate Independent Study
  • BME 791: Graduate Independent Study
  • BME 713S: QBio Seminar Series
  • BME 590: Special Topics in Biomedical Engineering
  • BME 574: Modeling and Engineering Gene Circuits (GE, MC)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 394: Projects in Biomedical Engineering (GE)
  • BIOLOGY 293-1: Research Independent Study

In the News

Representative Publications

  • Li, Z; Shen, Q; Usher, ET; Anderson, AP; Iburg, M; Lin, R; Zimmer, B; Meyer, MD; Holehouse, AS; You, L; Chilkoti, A; Dai, Y; Lu, GJ, Phase transition of GvpU regulates gas vesicle clustering in bacteria., Nature microbiology, vol 9 no. 4 (2024), pp. 1021-1035 [10.1038/s41564-024-01648-3] [abs].
  • Hamrick, GS; Maddamsetti, R; Son, H-I; Wilson, ML; Davis, HM; You, L, Programming Dynamic Division of Labor Using Horizontal Gene Transfer., ACS synthetic biology, vol 13 no. 4 (2024), pp. 1142-1151 [10.1021/acssynbio.3c00615] [abs].
  • Wang, T; Weiss, A; You, L, A generic approach to infer community-level fitness of microbial genes., Proceedings of the National Academy of Sciences of the United States of America, vol 121 no. 17 (2024) [10.1073/pnas.2318380121] [abs].
  • Luo, N; Lu, J; Şimşek, E; Silver, A; Yao, Y; Ouyang, X; West, SA; You, L, The collapse of cooperation during range expansion of Pseudomonas aeruginosa., Nature microbiology (2024) [10.1038/s41564-024-01627-8] [abs].
  • Maddamsetti, R; Yao, Y; Wang, T; Gao, J; Huang, VT; Hamrick, GS; Son, H-I; You, L, Duplicated antibiotic resistance genes reveal ongoing selection and horizontal gene transfer in bacteria., Nature communications, vol 15 no. 1 (2024) [10.1038/s41467-024-45638-9] [abs].