Geoffrey Steven Ginsburg

Ginsburg

Adjunct Professor in the Department of Medicine

Dr. Geoffrey S. Ginsburg's research interests are in the development of novel paradigms for developing and translating genomic information into medical practice and the integration of personalized medicine into health care.

Appointments and Affiliations

  • Adjunct Professor in the Department of Medicine
  • Professor of Biostatistics and Bioinformatics
  • Professor in the School of Nursing
  • Professor in Pathology
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: 101 Science Dr, Rm 2111, Ciemas Bldg, Durham, NC 27708
  • Office Phone: +1 919 668 6210
  • Email Address: geoffrey.ginsburg@duke.edu
  • Websites:

Education

  • Children's Hospital, Boston, 1990
  • Beth Israel Deaconess Medical Center, 1990
  • Beth Israel Deaconess Medical Center, 1987
  • Ph.D. Boston University, 1984
  • M.D. Boston University, 1984

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Manolio, TA; Abramowicz, M; Al-Mulla, F; Anderson, W; Balling, R; Berger, AC; Bleyl, S; Chakravarti, A; Chantratita, W; Chisholm, RL; Dissanayake, VHW; Dunn, M; Dzau, VJ; Han, B-G; Hubbard, T; Kolbe, A; Korf, B; Kubo, M; Lasko, P; Leego, E; Mahasirimongkol, S; Majumdar, PP; Matthijs, G; McLeod, HL; Metspalu, A; Meulien, P; Miyano, S; Naparstek, Y; O'Rourke, PP; Patrinos, GP; Rehm, HL; Relling, MV; Rennert, G; Rodriguez, LL; Roden, DM; Shuldiner, AR; Sinha, S; Tan, P; Ulfendahl, M; Ward, R; Williams, MS; Wong, JEL; Green, ED; Ginsburg, GS, Global implementation of genomic medicine: We are not alone., Sci Transl Med, vol 7 no. 290 (2015) [10.1126/scitranslmed.aab0194] [abs].
  • Dzau, VJ; Ginsburg, GS; Van Nuys, K; Agus, D; Goldman, D, Aligning incentives to fulfil the promise of personalised medicine., Lancet, vol 385 no. 9982 (2015), pp. 2118-2119 [10.1016/S0140-6736(15)60722-X] [abs].
  • Benjamin, AM; Nichols, M; Burke, TW; Ginsburg, GS; Lucas, JE, Comparing reference-based RNA-Seq mapping methods for non-human primate data., BMC Genomics, vol 15 no. 1 (2014) [10.1186/1471-2164-15-570] [abs].
  • Power, A; Berger, AC; Ginsburg, GS, Genomics-enabled drug repositioning and repurposing: insights from an IOM Roundtable activity., JAMA, vol 311 no. 20 (2014), pp. 2063-2064 [10.1001/jama.2014.3002] [abs].
  • Kraft, BD; Piantadosi, CA; Benjamin, AM; Lucas, JE; Zaas, AK; Betancourt-Quiroz, M; Woods, CW; Chang, AL; Roggli, VL; Marshall, CD; Ginsburg, GS; Welty-Wolf, K, Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates., Am J Respir Cell Mol Biol, vol 50 no. 5 (2014), pp. 995-1004 [10.1165/rcmb.2013-0340OC] [abs].
  • Ngo, HT; Wang, H-N; Burke, T; Ginsburg, GS; Vo-Dinh, T, Multiplex detection of disease biomarkers using SERS molecular sentinel-on-chip., Anal Bioanal Chem, vol 406 no. 14 (2014), pp. 3335-3344 [10.1007/s00216-014-7648-4] [abs].
  • Ginsburg, G, Medical genomics: Gather and use genetic data in health care., Nature, vol 508 no. 7497 (2014), pp. 451-453 [10.1038/508451a] [abs].
  • Tsalik, EL; Langley, RJ; Dinwiddie, DL; Miller, NA; Yoo, B; van Velkinburgh, JC; Smith, LD; Thiffault, I; Jaehne, AK; Valente, AM; Henao, R; Yuan, X; Glickman, SW; Rice, BJ; McClain, MT; Carin, L; Corey, GR; Ginsburg, GS; Cairns, CB; Otero, RM; Fowler, VG; Rivers, EP; Woods, CW; Kingsmore, SF, An integrated transcriptome and expressed variant analysis of sepsis survival and death., Genome Med, vol 6 no. 11 (2014) [10.1186/s13073-014-0111-5] [abs].
  • Voora, D; Cyr, D; Lucas, J; Chi, J-T; Dungan, J; McCaffrey, TA; Katz, R; Newby, LK; Kraus, WE; Becker, RC; Ortel, TL; Ginsburg, GS, Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events., J Am Coll Cardiol, vol 62 no. 14 (2013), pp. 1267-1276 [10.1016/j.jacc.2013.05.073] [abs].
  • Zaas, AK; Burke, T; Chen, M; McClain, M; Nicholson, B; Veldman, T; Tsalik, EL; Fowler, V; Rivers, EP; Otero, R; Kingsmore, SF; Voora, D; Lucas, J; Hero, AO; Carin, L; Woods, CW; Ginsburg, GS, A host-based RT-PCR gene expression signature to identify acute respiratory viral infection., Sci Transl Med, vol 5 no. 203 (2013) [10.1126/scitranslmed.3006280] [abs].
  • Langley, RJ; Tsalik, EL; van Velkinburgh, JC; Glickman, SW; Rice, BJ; Wang, C; Chen, B; Carin, L; Suarez, A; Mohney, RP; Freeman, DH; Wang, M; You, J; Wulff, J; Thompson, JW; Moseley, MA; Reisinger, S; Edmonds, BT; Grinnell, B; Nelson, DR; Dinwiddie, DL; Miller, NA; Saunders, CJ; Soden, SS; Rogers, AJ; Gazourian, L; Fredenburgh, LE; Massaro, AF; Baron, RM; Choi, AMK; Corey, GR; Ginsburg, GS; Cairns, CB; Otero, RM; Fowler, VG; Rivers, EP; Woods, CW; Kingsmore, SF, An integrated clinico-metabolomic model improves prediction of death in sepsis., Sci Transl Med, vol 5 no. 195 (2013) [10.1126/scitranslmed.3005893] [abs].
  • Wang, H-N; Fales, AM; Zaas, AK; Woods, CW; Burke, T; Ginsburg, GS; Vo-Dinh, T, Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics., Anal Chim Acta, vol 786 (2013), pp. 153-158 [10.1016/j.aca.2013.05.017] [abs].
  • Ginsburg, GS, Realizing the opportunities of genomics in health care., JAMA, vol 309 no. 14 (2013), pp. 1463-1464 [10.1001/jama.2013.1465] [abs].
  • Khoury, MJ; Lam, TK; Ioannidis, JPA; Hartge, P; Spitz, MR; Buring, JE; Chanock, SJ; Croyle, RT; Goddard, KA; Ginsburg, GS; Herceg, Z; Hiatt, RA; Hoover, RN; Hunter, DJ; Kramer, BS; Lauer, MS; Meyerhardt, JA; Olopade, OI; Palmer, JR; Sellers, TA; Seminara, D; Ransohoff, DF; Rebbeck, TR; Tourassi, G; Winn, DM; Zauber, A; Schully, SD, Transforming epidemiology for 21st century medicine and public health., Cancer Epidemiol Biomarkers Prev, vol 22 no. 4 (2013), pp. 508-516 [10.1158/1055-9965.EPI-13-0146] [abs].
  • Orlando, LA; Buchanan, AH; Hahn, SE; Christianson, CA; Powell, KP; Skinner, CS; Chesnut, B; Blach, C; Due, B; Ginsburg, GS; Henrich, VC, Development and validation of a primary care-based family health history and decision support program (MeTree)., N C Med J, vol 74 no. 4 (2013), pp. 287-296 [abs].
  • Henao, R; Murray, J; Ginsburg, G; Carin, L; Lucas, JE, Patient clustering with uncoded text in electronic medical records., AMIA Annu Symp Proc, vol 2013 (2013), pp. 592-599 [abs].
  • Ginsburg, GS; Kuderer, NM, Comparative effectiveness research, genomics-enabled personalized medicine, and rapid learning health care: a common bond., J Clin Oncol, vol 30 no. 34 (2012), pp. 4233-4242 [10.1200/JCO.2012.42.6114] [abs].
  • Zarco, MF; Vess, TJ; Ginsburg, GS, The oral microbiome in health and disease and the potential impact on personalized dental medicine., Oral Dis, vol 18 no. 2 (2012), pp. 109-120 [10.1111/j.1601-0825.2011.01851.x] [abs].
  • Orlando, LA; Hauser, ER; Christianson, C; Powell, KP; Buchanan, AH; Chesnut, B; Agbaje, AB; Henrich, VC; Ginsburg, G, Protocol for implementation of family health history collection and decision support into primary care using a computerized family health history system., BMC Health Serv Res, vol 11 (2011) [10.1186/1472-6963-11-264] [abs].
  • Ginsburg, GS; Staples, J; Abernethy, AP, Academic medical centers: ripe for rapid-learning personalized health care., Sci Transl Med, vol 3 no. 101 (2011) [10.1126/scitranslmed.3002386] [abs].
  • Chen, M; Zaas, A; Woods, C; Ginsburg, GS; Lucas, J; Dunson, D; Carin, L, Predicting Viral Infection From High-Dimensional Biomarker Trajectories., J Am Stat Assoc, vol 106 no. 496 (2011), pp. 1259-1279 [10.1198/jasa.2011.ap10611] [abs].
  • Chan, IS; Ginsburg, GS, Personalized medicine: progress and promise., Annu Rev Genomics Hum Genet, vol 12 (2011), pp. 217-244 [10.1146/annurev-genom-082410-101446] [abs].
  • Altshuler, JS; Balogh, E; Barker, AD; Eck, SL; Friend, SH; Ginsburg, GS; Herbst, RS; Nass, SJ; Streeter, CM; Wagner, JA, Opening up to precompetitive collaboration., Sci Transl Med, vol 2 no. 52 (2010) [10.1126/scitranslmed.3001515] [abs].
  • Ginsburg, GS, Regression of atherosclerosis with therapeutic antibodies pipe cleaner or pipe dream?, J Am Coll Cardiol, vol 50 no. 24 (2007), pp. 2319-2321 [10.1016/j.jacc.2007.08.039] [abs].
  • Lugogo, NL; Ginsburg, GS; Que, LG, Genetic profiling and tailored therapy in asthma: are we there yet?, Curr Opin Mol Ther, vol 9 no. 6 (2007), pp. 528-537 [abs].
  • Ginsburg, GS; Shah, SH; McCarthy, JJ, Taking cardiovascular genetic association studies to the next level., J Am Coll Cardiol, vol 50 no. 10 (2007), pp. 930-932 [10.1016/j.jacc.2007.05.025] [abs].
  • Parker, A; Izmailova, ES; Narang, J; Badola, S; Le, T; Roubenoff, R; Ginsburg, GS; Maier, A; Coblyn, JS; Shadick, NA; Weinblatt, ME, Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate., J Rheumatol, vol 34 no. 9 (2007), pp. 1817-1822 [abs].
  • Dressman, HK; Muramoto, GG; Chao, NJ; Meadows, S; Marshall, D; Ginsburg, GS; Nevins, JR; Chute, JP, Gene expression signatures that predict radiation exposure in mice and humans., PLoS Med, vol 4 no. 4 (2007) [10.1371/journal.pmed.0040106] [abs].
  • Dressman, HK; Berchuck, A; Chan, G; Zhai, J; Bild, A; Sayer, R; Cragun, J; Clarke, J; Whitaker, RS; Li, L; Gray, J; Marks, J; Ginsburg, GS; Potti, A; West, M; Nevins, JR; Lancaster, JM, An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer., J Clin Oncol, vol 25 no. 5 (2007), pp. 517-525 [10.1200/JCO.2006.06.3743] [abs].
  • Potti, A; Dressman, HK; Bild, A; Riedel, RF; Chan, G; Sayer, R; Cragun, J; Cottrill, H; Kelley, MJ; Petersen, R; Harpole, D; Marks, J; Berchuck, A; Ginsburg, GS; Febbo, P; Lancaster, J; Nevins, JR, Genomic signatures to guide the use of chemotherapeutics., Nat Med, vol 12 no. 11 (2006), pp. 1294-1300 [10.1038/nm1491] [abs].
  • Ginsburg, GS; Seo, D; Frazier, C, Microarrays coming of age in cardiovascular medicine: standards, predictions, and biology., J Am Coll Cardiol, vol 48 no. 8 (2006), pp. 1618-1620 [10.1016/j.jacc.2006.07.025] [abs].
  • Ginsburg, GS; Angrist, M; Cook-Deegan, R, Public health. Genomics and medicine at a crossroads in Chernobyl., Science, vol 314 no. 5796 (2006), pp. 62-63 [10.1126/science.1130274] [abs].
  • Stallings, SC; Huse, D; Finkelstein, SN; Crown, WH; Witt, WP; Maguire, J; Hiller, AJ; Sinskey, AJ; Ginsburg, GS, A framework to evaluate the economic impact of pharmacogenomics., Pharmacogenomics, vol 7 no. 6 (2006), pp. 853-862 [10.2217/14622416.7.6.853] [abs].
  • Potti, A; Mukherjee, S; Petersen, R; Dressman, HK; Bild, A; Koontz, J; Kratzke, R; Watson, MA; Kelley, M; Ginsburg, GS; West, M; Harpole, DH; Nevins, JR, A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer., N Engl J Med, vol 355 no. 6 (2006), pp. 570-580 [10.1056/NEJMoa060467] [abs].
  • Seo, D; Ginsburg, GS; Goldschmidt-Clermont, PJ, Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications., J Am Coll Cardiol, vol 48 no. 2 (2006), pp. 227-235 [10.1016/j.jacc.2006.02.070] [abs].
  • Haga, SB; Ginsburg, GS, Prescribing BiDil: is it black and white?, J Am Coll Cardiol, vol 48 no. 1 (2006), pp. 12-14 [10.1016/j.jacc.2006.04.017] [abs].
  • Cotten, CM; Ginsburg, GS; Goldberg, RN; Speer, MC, Genomic analyses: a neonatology perspective., J Pediatr, vol 148 no. 6 (2006), pp. 720-726 [10.1016/j.jpeds.2006.01.006] [abs].
  • West, M; Ginsburg, GS; Huang, AT; Nevins, JR, Embracing the complexity of genomic data for personalized medicine., Genome Res, vol 16 no. 5 (2006), pp. 559-566 [10.1101/gr.3851306] [abs].
  • Ginsburg, GS; Haga, SB, Translating genomic biomarkers into clinically useful diagnostics., Expert Rev Mol Diagn, vol 6 no. 2 (2006), pp. 179-191 [10.1586/14737159.6.2.179] [abs].
  • Ginsburg, GS; Konstance, RP; Allsbrook, JS; Schulman, KA, Implications of pharmacogenomics for drug development and clinical practice., Arch Intern Med, vol 165 no. 20 (2005), pp. 2331-2336 [10.1001/archinte.165.20.2331] [abs].
  • Ginsburg, GS; Donahue, MP; Newby, LK, Prospects for personalized cardiovascular medicine: the impact of genomics., J Am Coll Cardiol, vol 46 no. 9 (2005), pp. 1615-1627 [10.1016/j.jacc.2005.06.075] [abs].
  • Willard, HF; Angrist, M; Ginsburg, GS, Genomic medicine: genetic variation and its impact on the future of health care., Philos Trans R Soc Lond B Biol Sci, vol 360 no. 1460 (2005), pp. 1543-1550 [10.1098/rstb.2005.1683] [abs].
  • Seo, D; Ginsburg, GS, Genomic medicine: bringing biomarkers to clinical medicine., Curr Opin Chem Biol, vol 9 no. 4 (2005), pp. 381-386 [10.1016/j.cbpa.2005.06.009] [abs].
  • Abrahams, E; Ginsburg, GS; Silver, M, The Personalized Medicine Coalition: goals and strategies., Am J Pharmacogenomics, vol 5 no. 6 (2005), pp. 345-355 [10.2165/00129785-200505060-00002] [abs].
  • Ross, JS; Schenkein, DP; Pietrusko, R; Rolfe, M; Linette, GP; Stec, J; Stagliano, NE; Ginsburg, GS; Symmans, WF; Pusztai, L; Hortobagyi, GN, Targeted therapies for cancer 2004., Am J Clin Pathol, vol 122 no. 4 (2004), pp. 598-609 [10.1309/5CWP-U41A-FR1V-YM3F] [abs].
  • Ross, JS; Ginsburg, GS, Integration of molecular diagnostics with therapeutics: implications for drug discovery and patient care., Expert Rev Mol Diagn, vol 2 no. 6 (2002), pp. 531-541 [10.1586/14737159.2.6.531] [abs].
  • Meyer, JM; Ginsburg, GS, The path to personalized medicine., Curr Opin Chem Biol, vol 6 no. 4 (2002), pp. 434-438 [10.1016/s1367-5931(02)00340-x] [abs].
  • Ginsburg, GS; McCarthy, JJ, Personalized medicine: revolutionizing drug discovery and patient care., Trends Biotechnol, vol 19 no. 12 (2001), pp. 491-496 [10.1016/s0167-7799(01)01814-5] [abs].