Steven B. Haase
Associate Professor of Biology
Our group is broadly interested in understanding the biological clock mechanisms that control the timing of events during the cell division cycle. In 2008, the Haase group proposed a new model in which a complex network of sequentially activated transcription factors regulates the precise timing of gene expression during the cell-cycle, and functions as a robust time-keeping oscillator. Greater than a thousand genes are expressed at distinct phases of the cycle, and the control network itself consists of ~20 components, so this dynamical system is far too complex to understand simply by biological intuition. We rely heavily on the expertise of the Harer group (Dept. of Mathematics, Duke University) for the analysis of complex data, and their understanding of dynamical systems. Using a collection of tools, including molecular genetics, genomics, mathematical models, and statistical inference, our groups aim to understand how the cell division clock works, how it might be perturbed in proliferative diseases such as cancer, and how the clock components might be targeted for new anti-tumor therapies. Qualitatively, the clock networks that control the yeast cell cycle look much like the networks controlling circadian rhythms in a variety of organisms. More recently, we have been using our experimental and quantitative approaches to investigate the function of circadian clocks, as well as clocks that control the division and development of pathogenic organisms such as P. falciparum and P. vivax, the causative agents of malaria.
Appointments and Affiliations
- Associate Professor of Biology
- Associate Professor in Medicine
- Office Location: 4316 French, Durham, NC 27708
- Office Phone: (919) 613-8205
- Email Address: email@example.com
- Ph.D. Stanford University, 1993
- B.S. Colorado State University, 1985
- BIOLOGY 218: Biological Clocks: How Organisms Keep Time
- BIOLOGY 432S: Biology of Host-Pathogen Interactions
- BIOLOGY 490S: Special Topics Seminar
- BIOLOGY 728D: University Program in Genetics and Genomics Biological Solutions Module IV
- CMB 778D: University Program in Genetics and Genomics Biological Solutions Module IV
- MATH 183: Biological Clocks: How Organisms Keep Time
- MGM 778D: University Program in Genetics and Genomics Biological Solutions Module IV
- UPGEN 701: Advanced Topics in Genetics and Genomics
- UPGEN 750S: Genetics Colloquium
- UPGEN 778C: University Program in Genetics and Genomics Biological Solutions Module Ill
- UPGEN 778D: University Program in Genetics and Genomics Biological Solutions Module IV
- UPGEN 778E: University Program in Genetics and Genomics Biological Solutions Module V
In the News
- Comparing the Swab to the Sewer (Mar 4, 2021 | Pratt School of Engineering)
- ‘They’re not ready’: Students are about to flood college campuses. The virus could, too. (Dec 7, 2020 | Politico)
- Duke has several contingency plans for start of spring semester (Nov 20, 2020)
- COVID Testing Keeps A Campus Safe: The Duke Experience | Media Briefing (Nov 18, 2020)
- STUDENTS 'NOTHING SHORT OF PHENOMENAL' IN MINIMIZING COVID SPREAD (Nov 18, 2020)
- CASE STUDY: DUKE'S AGGRESSIVE COVID TESTING AND SURVEILLANCE MINIMIZED INFECTION (Nov 16, 2020)
- Meet the Team Powering Duke’s COVID-19 Surveillance Testing Efforts (Aug 24, 2020)
- KEEPING A CLOSE WATCH ON COVID-19 WITH SURVEILLANCE TESTS (Aug 19, 2020)
- Malaria Parasite Ticks to its Own Internal Clock (May 14, 2020)
- Malaria Parasites’ Biological Clocks Coordinate Cell Destruction (May 14, 2020)
- Discovery of Malaria Parasite’s Clock Could Pave Way to New Treatments (May 14, 2020)
- Biological Clocks May Be Our Next Defense Against Malaria (Mar 7, 2019)
- Researchers Win $189,800 to Bridge Data Science, Cell Cycle Control (Oct 1, 2018)
- Denny, TN; Andrews, L; Bonsignori, M; Cavanaugh, K; Datto, MB; Deckard, A; DeMarco, CT; DeNaeyer, N; Epling, CA; Gurley, T; Haase, SB; Hallberg, C; Harer, J; Kneifel, CL; Lee, MJ; Louzao, R; Moody, MA; Moore, Z; Polage, CR; Puglin, J; Spotts, PH; Vaughn, JA; Wolfe, CR, Implementation of a Pooled Surveillance Testing Program for Asymptomatic SARS-CoV-2 Infections on a College Campus - Duke University, Durham, North Carolina, August 2-October 11, 2020., Mmwr. Morbidity and Mortality Weekly Report, vol 69 no. 46 (2020), pp. 1743-1747 [10.15585/mmwr.mm6946e1] [abs].
- Smith, LM; Motta, FC; Chopra, G; Moch, JK; Nerem, RR; Cummins, B; Roche, KE; Kelliher, CM; Leman, AR; Harer, J; Gedeon, T; Waters, NC; Haase, SB, An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum., Science (New York, N.Y.), vol 368 no. 6492 (2020), pp. 754-759 [10.1126/science.aba4357] [abs].
- Cho, C-Y; Kelliher, CM; Haase, SB, The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle., Cell Cycle, vol 18 no. 4 (2019), pp. 363-378 [10.1080/15384101.2019.1570655] [abs].
- Saelens, JW; Petersen, JE; Freedman, B; Haase, SB; Taylor, SM, COMPARATIVE TRANSCRIPTOMICS OF PLASMODIUM FALCIPARUM IN NORMAL AND SICKLE-TRAIT ERYTHROCYTES USING RNA SEQUENCING, The American Journal of Tropical Medicine and Hygiene, vol 101 (2019), pp. 500-500 [abs].
- Kelliher, CM; Foster, MW; Motta, FC; Deckard, A; Soderblom, EJ; Moseley, MA; Haase, SB, Layers of regulation of cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae., Molecular Biology of the Cell, vol 29 no. 22 (2018), pp. 2644-2655 [10.1091/mbc.E18-04-0255] [abs].